Alice Fike, C.R.N.P

Clinical Operations Manager

Clinical Care and Research

Summary

CDR Alice Fike obtained a BS in Nursing from Syracuse University. After serving as a Peace Corps health volunteer in rural Burkina Faso, she obtained a MS in Nursing at the University of California, San Francisco as a nurse practitioner. Her career focus is providing care for marginalized communities. CDR Fike is a U.S. Public Health Service officer with training and experience in infectious disease surveillance and control and is fluent in French and Spanish. She holds an advanced practice certification in rheumatology and has worked with NIAMS in the Office of the Clinical Director since 2009 with a two-year tour in Niger at the U.S. Embassy from 2016-2018. She has also supported clinical care for the Lupus Clinical Trials Unit, the Vasculitis Translational Research Program, and the Clinical Rheumatology Fellowship program.

CDR Fike was named the Clinical Operations Manager for NIAMS IRP in April 2025. In this role, she leads clinical trial quality assurance and improvement activities for NIAMS ensuring regulatory compliance and leads clinical resource allocation and operations for the IRP. She continues to see patients with VEXAS Syndrome with the Vasculitis Translational Research Program. In her personal capacity, she works part time at a local free clinic.

Research Statement

Commander Fike's research interests include rheumatology health disparities, VEXAS syndrome, and infectious complications of rheumatic diseases.

Scientific Publications

Discontinuation versus continuation of maintenance treatment with tumor necrosis factor inhibitors in patients with rheumatoid arthritis with low disease activity or remission: A randomized double-blind placebo-controlled trial.

Ward MM, Weinstein A, Alejandro-Silva P, Matsumoto AK, Konatalapalli R, Stahl N, Kerr GS, Mikdashi J, Kempf P, Shah NR, Danielides S, Ghafouri M, Olenginski TP, Fike A, Balyozova-Dinkov D, Thiele R, Yao L, Paul S, Constantinescu F
Semin Arthritis Rheum.
2025 Dec;
75().
doi: 10.1016/j.semarthrit.2025.152831
PMID: 41045868

Disease Trajectories and Glucocorticoid Exposure in VEXAS Syndrome Treated with Cytokine-Directed Therapies.

Turturice BA, Fike A, Patel BA, Groarke EM, Gutierrez-Rodriguez F, Stonick K, Berrett H, Liu S, Darden I, Quinn KA, Young NS, Grayson PC
Ann Rheum Dis.
2026 Feb;
85(2).
doi: 10.1016/j.ard.2025.05.021
PMID: 40581580

Opportunistic Infections, Mortality Risk, and Prevention Strategies in Patients With Vacuoles, E1 Enzyme, X-Linked, Autoinflammatory, Somatic (VEXAS) Syndrome.

Czech M, Cuellar-Rodriguez J, Patel BA, Groarke EM, Cowen EW, Turturice B, Beck DB, Wilson L, Goodspeed W, Darden I, Young NS, Hickstein D, Ombrello A, Hoffman P, Arikan EA, Sinaii N, Hathaway L, Castelo-Soccio L, Fike A, Kastner DB, Grayson PC, Ferrada MA
Open Forum Infect Dis.
2024 Jul;
11(7).
doi: 10.1093/ofid/ofae405
PMID: 39077052

Risk Factors for COVID-19 and Rheumatic Disease Flare in a US Cohort of Latino Patients.

Fike A, Hartman J, Redmond C, Williams SG, Ruiz-Perdomo Y, Chu J, Hasni S, Ward MM, Katz JD, Gourh P
Arthritis Rheumatol.
2021 Jul;
73(7).
doi: 10.1002/art.41656
PMID: 33455077

Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia.

Kennedy SB, Bolay F, Kieh M, Grandits G, Badio M, Ballou R, Eckes R, Feinberg M, Follmann D, Grund B, Gupta S, Hensley L, Higgs E, Janosko K, Johnson M, Kateh F, Logue J, Marchand J, Monath T, Nason M, Nyenswah T, Roman F, Stavale E, Wolfson J, Neaton JD, Lane HC, PREVAIL I Study Group
N Engl J Med.
2017 Oct 12;
377(15).
doi: 10.1056/NEJMoa1614067
PMID: 29020589

A pilot study of yoga as self-care for arthritis in minority communities.

Middleton KR, Ward MM, Haaz S, Velummylum S, Fike A, Acevedo AT, Tataw-Ayuketah G, Dietz L, Mittleman BB, Wallen GR
Health Qual Life Outcomes.
2013 Apr 2;
11().
doi: 10.1186/1477-7525-11-55
PMID: 23548052
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