RNA binding proteins (RBPs) are a large and diverse class of proteins. They are encoded by more than 1,500 genes in humans. RBPs control every aspect of RNA metabolism and posttranscriptionally regulate gene expression. However, identifying RBPs is challenging because many of them lack clearly identifiable features and are involved in processes not necessarily thought to be RNA related, such as metabolism (all the chemical changes that occur in a cell to break down a molecule).

Neutrophils are essential first responders in the immune system, playing a significant role in various diseases. This method will be helpful in neutrophil-targeted drug development by offering real-time, high-throughput screening.

This case report is the first description of topical ruxolitinib—a JAK inhibitor—improving skin rash in two patients with JDM or DM who did not improve with other treatments.

Findings from this study provide additional knowledge about the different species and subspecies of staphylococci that live on the human skin and how these different types of bacteria have adapted to varied skin areas.

Testing for MAA may be clinically useful in children with myositis. Given the association between MAA and severe disease, children with myositis who have one or more MAA types may need to receive more aggressive treatment than those without these autoantibodies.

According to the report, mutations of UBA1 in hematopoietic stem cells appear to cause abnormal inflammation and myeloid predominance in VEXAS syndrome.

A physician should be aware of the ophthalmological effects of autoinflammatory diseases, particularly this new entity called the VEXAS syndrome.

The study reports the use of urine as a biomarker source for JDM.

The study characterizes the colonization of eukaryotic RNA viruses in RAG-deficient patient population and also demonstrates the importance of these patients as potential reservoirs of viral persistence and evolution.

Early diagnosis and interventions have improved the quality of life for STAT3DN patients.

The modified clinical algorithm allows for faster diagnosis and treatment of children with APECED syndrome.

The study identifies several novel SLE susceptibility genes in an ancestrally diverse childhood-onset lupus cohort.

CD271 could be a promising pharmaceutical target for the treatment of cutaneous squamous cell carcinoma.

Recombinant amphiregulin could be a potential therapeutic agent for cutaneous I/R injury.

Hypodermal macrophages play an important role in infection outcomes in the skin.