Displaying 441 - 460 of 1020 results

Researchers Identify a Disease-Causing Immune Cell Imbalance in Lupus

https://www.niams.nih.gov/es/node/15256

Overview A team of NIAMS-funded researchers discovered an imbalance of T cell subtypes in patients with lupus that contributes to ongoing production of disease-causing autoantibodies. Compared to healthy individuals, patients with lupus have more T cells with specialized B cell helper functions and fewer T cells that are important for wound healing and maintaining the epithelial barrier, which acts to protect the body from pathogens and other invaders. The team identified two molecules that control this imbalance, which could be the targets of lupus treatments in the future. The study was recently published in the journal Nature. Background Systemic lupus
CLINICAL

Skin Manifestations of VEXAS Syndrome and Associated Genotypes May Aid in Quicker Diagnosis

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NIAMS IRP
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NIAMS IRP
A team of researchers in the Dermatology Consultation Service analyzed tissue samples from 60 of 112 study participants who were referred to the NIH Clinical Center in Bethesda, MD, for suspected VEXAS syndrome. The most reported findings included inflammation of the small blood vessels of the skin, known as leukocystoclastic vasculitis, fever and a painful rash known as neutrophilic dermatosis, and inflammation of the skin around the blood vessels, known as perivascular dermatitis.
Clinical Research Genetics and Genomics Immunology Skin Biology

Array of Patient Recruitment Efforts Boost Back Pain Study Participation

https://www.niams.nih.gov/es/node/15281

Back pain is one of the most common forms of chronic pain affecting adults. People with chronic back pain often take opioids for pain management, but opioids are highly addictive. To address this public health challenge, in 2019 NIH launched the Back Pain Consortium (BACPAC) Research Program, part of the NIH Helping to End Addiction Long-term® (HEAL) Initiative that launched in 2018, a patient-centered effort to address the need for non-addictive, effective and personalized therapies for chronic back pain. Scientists are conducting clinical trials with the hopes of finding new non-opioid treatments. Yet for clinical trials to be effective, the
BASIC

A computational method to improve analysis of single cell RNA-sequencing

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NIAMS IRP
In this report, researchers described a deep neural generative framework, the dynamic batching adversarial autoencoder (DB-AAE), which excels at denoising scRNA-seq datasets. DB-AAE directly captures optimal features from input data and enhances feature preservation, including cell type-specific gene expression patterns.
Computational Biology Genetics and Genomics
BASIC

HLA-B27 does not trigger gut inflammation through the unfolded protein response

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NIAMS IRP
Spondyloarthritis (SpA) is an inflammatory disease that affects the gastrointestinal tract, skeleton, and eyes. HLA-B27 is a major risk gene for SpA, but the underlying mechanisms are unclear. One hypothesis is that HLA-B27 promotes SpA through misfolding-induced endoplasmic reticulum (ER) stress that in turn upregulates IL-23 expression via the transcription factor CHOP. In this study, the researchers knocked out CHOP expression in an animal model of HLA-B27-associated SpA. Despite reduced IL-23 production, gut inflammation did not improve, indicating that the gut disease did not occur as a result of ER stress-induced IL-23 production.
Genetics and Genomics Immunology Molecular Biology and Biochemistry
CLINICAL

Genetic variants of hemophagocytic lymphohistiocytosis genes are enriched in children with systemic juvenile idiopathic arthritis

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NIAMS IRP
Familial hemophagocytic lymphohistiocytosis (HLH) is a life-threatening cytokine storm syndrome caused by recessive, loss of function variants of genes in the pathway that controls the processing of cytolytic granule processing pathway genes. Heterozygous variants in these genes contribute to a secondary form of HLH (macrophage activation syndrome, MAS) that frequently develops in children with systemic juvenile idiopathic arthritis (sJIA). To evaluate the relationship between HLH gene variation and sJIA without MAS, HLH genes were sequenced and compared between 524 patients with sJIA and 2,924 control patients.
Autoimmunity Genetics and Genomics

Resources from Around the NIH

https://www.niams.nih.gov/es/node/15381

Use these resources from our partners at other NIH institutes and centers to help improve your application, find additional support, meet new collaborators, or advance your career. Finding Your Place at NIH Find your Program Officer or Review Officer: Center for Scientific Review's (CSR's) Assisted Referral Tool: This tool was

Jordan Hicks, B.S.

https://www.niams.nih.gov/es/node/14646

Jordan is a current postbaccalaureate fellow at NIAMS. She works under the supervision of Dr. Pravitt Gourh as a part of the Scleroderma Genomics and Health Disparities Unit. Upon completion of her fellowship, she plans to pursue an MD.

DC Lupus Consortium - 30th Anniversary of Lupus Clinical Research

https://www.niams.nih.gov/es/node/14691

This event will highlight the outstanding progress in lupus clinical research made by NIH over the last 30 years, featuring testimonials from research participants, updates on current lupus research activities at NIAMS, and discussions on the future direction of research at the NIH. The event seeks to build on the success of DC Lupus Consortium- a platform to collaborate between NIH scientists, physicians outside the NIH and patient advocacy groups interested in Lupus Clinical Research.

Typically materials from NIAMS that are more than 5 years old will be archived.

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