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In Myositis, Autoantibodies Get Inside Muscle Cells and Disrupt the Function of the Proteins They Bind To

https://www.niams.nih.gov/es/node/14846

Overview An international team of researchers, led by the NIAMS Intramural Research Program (IRP)’s Muscle Disease Section, has discovered a new mechanism through which myositis autoantibodies —antibodies produced by the immune system that mistakenly target the body's own components— contribute to the disease. Myositis encompasses a group of rare autoimmune diseases where the immune system mistakenly attacks healthy muscle tissue. The researchers discovered that autoantibodies can get inside muscle cells and disrupt the normal function of the proteins they bind to. This new discovery could have implications for how we understand not only myositis, but also other autoimmune diseases. The
CLINICAL

Younger People With Merkel Cell Carcinoma Often Carry Genetic Risk Factors for Other Cancers

Merkel cell carcinoma is an aggressive skin cancer that occurs when nerve-like cells that produce hormones (called neuroendocrine cells) grow out of control. The disease is rare in people under age 50. Genetic screenings of people with early onset Merkel cell carcinoma show that 19 percent had well-described variants in genes associated with an increased likelihood of cancer development.
Cancer Biology Computational Biology Skin Biology
TRANSLATIONAL

As People With Vasculitis Get Older, They Acquire Blood Cell Mutations That May Cause Inflammation

Clonal hematopoiesis is a term to describe a process where healthy individuals acquire genetic mutations in their blood cells later in life. Cells that carry these mutations promote inflammation, which increases risk of death due to cardiovascular disease.
Autoimmunity Clinical Research Computational Biology Genetics and Genomics Immunology

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