Research Progress Related to Sjögren’s Disease
Investigators at the National Institutes of Health (NIH), as well as investigators across the country, many supported by the NIH, are working to understand what causes Sjögren’s disease, which may lead to new treatment strategies. A number of efforts are also aimed at testing the efficacy of medications that have been shown to work for other autoimmune diseases.
Following are examples of the types of studies that are ongoing.
- Scientists are working to uncover the molecules and immune cells involved in the autoimmune attack in Sjögren’s disease. This work may help identify new therapeutic targets. One such initiative, the Accelerating Medicines Partnership® Autoimmune and Immune-Mediated Diseases (AMP® AIM) Program, aims to accelerate new and effective therapies to patients with Sjogren’s and other autoimmune diseases.
- Clinical trials are underway to test the efficacy of disease-modifying anti-rheumatic drugs in people with Sjögren’s disease. Some of these drugs are novel, while others are used to treat other rheumatic conditions. They work by targeting specific immune messages and interrupting the signal, helping to decrease or stop inflammation.
- Researchers believe that genetics is a contributing factor in who gets Sjögren’s disease, but the role of genes remains unclear. It appears that multiple genes are involved, and research is underway to identify them.
- The characteristics of Sjögren’s disease can vary widely from person to person, and investigators are working to group patients according to patterns of symptoms, which will help researchers develop tailored therapies that better address the problems associated with each subset.
- It can take years to diagnose Sjögren’s disease because the symptoms are so diverse, and they are shared with other diseases and conditions. Scientists are looking for ways to diagnose the disease earlier, such as by identifying biomarkers (substances in blood or tissues of people with the disease) or using imaging techniques such as ultrasound scanning of salivary glands. Pinpointing the disease earlier will enable doctors to treat it sooner, potentially leading to better outcomes for patients.
For more info
U.S. Food and Drug Administration
網站 https://www.fda.gov (en inglés)
Centers for Disease Control and Prevention, National Center for Health Statistics
網站 cdc.gov/nchs (en inglés)
National Eye Institute, National Institutes of Health
網站 https://www.nei.nih.gov (en inglés)
National Institute of Dental and Craniofacial Research, National Institutes of Health
網站 https://www.nidcr.nih.gov (en inglés)
National Institute of Neurological Disorders and Stroke, NIH Neurological Institute
網站 https://www.ninds.nih.gov (en inglés)
American Academy of Ophthalmology
網站 http://www.aao.org/ (en inglés)
American Association for Dental Research
網站 http://aadronline.org/ (en inglés)
American College of Rheumatology
網站 rheumatology.org (en inglés)
American Dental Association
網站 http://www.ada.org (en inglés)
Autoimmune Association
網站 autoimmune.org (en inglés)
Lupus Foundation of America
網站 lupus.org (en inglés)
The Myositis Association
網站 myositis.org (con información en español) (en inglés)
National Organization for Rare Disorders
網站 rarediseases.org (en inglés)
National Scleroderma Foundation
網站 scleroderma.org (en inglés)
Scleroderma Research Foundation
網站 srfcure.org (en inglés)
Sjögren's Foundation
網站 sjogrens.org (en inglés)
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