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Research in NIAMS Labs
Updated March 30, 2015
Siegel Lab Identifies TL1A As a Novel Cytokine that Contributes to IL-9-mediated Allergic Disease
New research from the Autoimmunity Branch reveals that TL1A-DR3 interactions contribute to the production of IL-9-secreting T cells and development of allergic lung inflammation. This study identifies the therapeutic potential of targeting TL1A for the treatment of IL-9-mediated allergic diseases. The image shows mucus in the airway (top right) and TL1A around the blood vessels (bottom right) of inflamed lung compared to healthy lung (left).
NIAMSí Intramural Research Programs Foster Spirit of Discovery
The Rheumatologist profiles investigators from NIAMS' IRP working in immunology and rheumatology, describing NIAMS' "long tradition of scientific innovation."
NIH Researchers Reveal Link Between Powerful Gene Regulatory Elements and Autoimmune Diseases
NIAMS research fellow Golnaz Vahedi and other NIH intramural and extramural investigators have discovered the genomic switches of a blood cell key to regulating the human immune system.
SIRT1 Links Metabolism to Gene Expression in Skeletal Muscle Stem Cells
Sirtuin 1 (SIRT1) is an enzyme that regulates gene expression by removing acetyl groups from DNA-associated proteins. New research from the Sartorelli lab reveals that metabolic changes affect SIRT1 activity, thus leading to altered gene expression in the stem cells of skeletal muscle.
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Clinical and Translational Research
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- NIH Researchers Reveal Link Between Powerful Gene Regulatory Elements and Autoimmune Diseases
- Research on Keratins Reveals Unexpected Link Between Hair Disorders and Dental Decay
- NIH immunologist elected to Institute of Medicine