Research in NIAMS Labs

Welcome to NIAMS Labs from Dr. John O'Shea, NIAMS Scientific Director

As you will see, our program comprises scientists, physicians, nurses, trainees and administrators who work together to solve basic scientific problems and devise new treatments for arthritis, musculoskeletal and skin diseases.

Click here to read the welcome message from the Scientific Director

Dr. O'Shea Publishes A Cover Review Article in Immunity Discussing JAK-STAT Signaling Pathway in Iimmuneregulation and Immune-Mediated Disease

The discovery of JAK-STAT Signaling provided a simple mechanism for gene regulation that dramatically advanced our understanding of the action of hormones, interferons, colony-stimulating factors, and interleukins.
Immunity, 2012, Volume 36, Issue 4, 542-550.

O'Shea Lab Publishes in Nature Immunology that miR-10a Fine-Tunes the Plasticity and Fate of Helper T cells

The study shows that naturally occurring regulatory T cells had high expression of the miR-10a, which was induced by retinoic acid and TGF-β in inducible T(reg) cells.
Nature Immunology , 2012, doi:10.1038/ni.2286

Read the abstract.

Morasso Lab Makes the Cover of Journal of Cell Science and Elucidates the Role of Retinoic Acid in Embryonic Skin Development

In this study, researchers ablated Cyp26b1 in skin in order to increase retinoic acid (RA) levels, and found that increased RA levels affect embryonic skin barrier formation and peridermal development (J Cell Sci. 2012 Apr 1;125(Pt 7):1827-36. doi: 10.1242/jcs.101550).

Read the abstract and the paper.

Casellas Lab Publishes in Nature that DNA Damage Defines Sites of recurrent chromosomal translocations in B Lymphocytes

Research showed that DNA break formation governs the location and frequency of recurrent translocations. The paper was published online on February 7, 2012 .

Read the abstract and the media availability.