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- In exchange for a two or three-year (for Intramural General Research) commitment to your research career, NIH will repay up to $35,000 per year of your qualified educational debt. See NIH Loan Repayment Programs
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Research in NIAMS Labs
Updated April 12, 2013
Welcome to NIAMS Labs from Dr. John O'Shea, NIAMS Scientific Director
As you will see, our program comprises scientists, physicians, nurses, trainees and administrators who work together to solve basic scientific problems and devise new treatments for arthritis, musculoskeletal and skin diseases.
Click here to read the welcome message from the Scientific Director
Clearing the Way to Make RNA in Muscle
The Sartorelli group has discovered that PolII, in conjunction with Spt6 and KDM6A, overcomes roadblocks like nucleosomes to transcribe genes in muscle cells. This cooperation between the three proteins controls developmental gene expression and cell differentiation.
Read the abstract here
Fontana and Steven Show the Structural Consequences at Low pH for the Influenza A Matrix Protein
The scientists demonstrated that at low pH, the M1 matrix protein of influenza A virus, which plays multiple roles in virus assembly and infection, undergoes a conformational change prior to dissociating from the membrane.
Read the abstract.
Casellas Group Develops a New DNA Damage Visualization Technique and Sheds Light on DNA Damage & Class Switching in Two Papers
The technique consists of detecting by immunoprecipitation and deep-sequencing recruitment of RPA to DNA breaks under conditions where homologous recombination is favored.
Cell Rep. 2013 Jan 1. doi:pii: S2211-1247(12)00431-7. 10.1016
Science. 2013 Jan 10.
Read the Cell Reports abstract and the Science abstract.
Dr. Steven Group Solves the Crystal Structure of Hepatitis B Virus e-antigen
The structure sheds light on a three-decades mystery and offers insight into how HBV e-antigen may establish immune tolerance for HBV core-antigen while evading its robust immunogenicity.
Structure . 2012 Dec 5. pii: S0969-2126(12)00414-5. doi: 10.1016/j.str.2012.10.017.
Read the abstract and the media availability.
Clinical and Translational Research
- NIAMS Clinical Trials and Natural History Studies at the NIH Campus
- NIAMS Sponsored Clinical Trials
- For all clinical trials click here
IRP News and Events
- NIH scientists shed light on mystery surrounding Hepatitis B virus discovery is decades in the making. More..
- NIH scientists uncover how immune cells sense who they are. More...
- New rheumatoid arthritis drug targets NIH-discovered protein. More...
- Major cancer protein amplifies global gene expression, NIH study finds. More...
