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Research in NIAMS Labs

Updated January 30, 2015

Photo of Dr. John O'Shea, NIAMS Scientific Director

Welcome to NIAMS Labs from Dr. John O'Shea, NIAMS Scientific Director

As you will see, our program comprises scientists, physicians, nurses, trainees and administrators who work together to solve basic scientific problems and devise new treatments for arthritis, musculoskeletal and skin diseases.

Illustration from Dr. Sartorelli's SIRT1 poster

SIRT1 Links Metabolism to Gene Expression in Skeletal Muscle Stem Cells

Sirtuin 1 (SIRT1) is an enzyme that regulates gene expression by removing acetyl groups from DNA-associated proteins. New research from the Sartorelli lab reveals that metabolic changes affect SIRT1 activity, thus leading to altered gene expression in the stem cells of skeletal muscle.

Illustration of a dartboard showing how AID targets super-enhancers.

Casellas lab identifies mechanisms that facilitate the formation of B cell tumors

This work identifies super-enhancers and key elements that recruit activation-induced cytidine deaminase (AID), thus leading to DNA strand breaks in B cell proto-oncogenes. These AID-induced mutations contribute to formation of B cell lymphomas.


Photo of Dr. Steven speaking at a podium.

Congratulations to Dr. Alasdair Steven

The chief of the NIAMS Laboratory of Structural Biology Research received the Eduard Kellenberger Medal from the International Federation of Societies for Microscopy. The award recognizes achievement in microscopy applications in the life sciences, including biology, medicine and related fields. Dr. Steven accepted the medal at the 2014 International Microscopy Congress in Prague.


Image showing damage (in color) to tooth enamel

Research on Keratins Reveals Unexpected Link Between Hair Disorders and Dental Decay

Keratins are proteins that are key structural components of hair, nails, and the skin’s outer layer. Now, new research has shown that certain types of hair keratin also help form dental enamel, the tough outer covering of teeth.