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Research in NIAMS Labs

Updated April 7, 2014

Photo of Dr. John O'Shea, NIAMS Scientific Director

Welcome to NIAMS Labs from Dr. John O'Shea, NIAMS Scientific Director

As you will see, our program comprises scientists, physicians, nurses, trainees and administrators who work together to solve basic scientific problems and devise new treatments for arthritis, musculoskeletal and skin diseases.

 Neutrophil extracellular traps are decorated with MMP-9 (red) that is able to activate endothelial MMP-2 ( lower left panel) and cause endothelial dysfunction ( upper right panel) in SLE patients.

Kaplan’s Lab Shows that Activation of Endothelial MMP-2 by MMP-9 Contributes to Endothelial Damage in SLE

This activation of MMP-2, when occurring within neutrophil extracellular traps, may perpetuate a vicious cycle leading to endothelial dysfunction.

Dr. Goldbach-Mansky

The American Association for Clinical Investigation (ASCI) has Selected Dr. Raphaela Goldbach-Mansky as a New Member

The ASCI is an honor society of physician-scientists who translate their research findings to clinical science and are in the upper ranks of academic medicine. Congratulations to Dr. Goldbach-Mansky.

Clustering of Fc epsilon receptor at 3min in response to high-affinity antigen. Images was obtained using TIRF microscopy

Rivera Lab Uncovers How Do Mast Cells Respond Differently to Strong vs. Weak Stimulus

The study, published in Science shows how the high-affinity IgE receptor deciphers high- from low-affinity stimulation to modulate mast cells’ effector responses.

The image depicts  the mouse species circumscribed within a polyhedral compound representing the promoter-enhancer interaction network.

Casellas Lab Maps the Interaction Between Mouse Gene Regulatory Domains

The scientists found that broadly expressed genes change their enhancer landscape during development, even for genes expressed in a wide range of tissues.
Cell, 155(7), pp: 1507–1520