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NIH Osteoporosis and Related Bone Diseases ~ National Resource Center

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Enlarged image showing osteoclasts (in red) and bone erosion.

Proteinís Role in Rheumatoid Arthritis-Induced Bone Loss Revealed

Investigators supported in part by NIAMS have shown how a protein called RBP-J controls a pathway that promotes bone degradation, a common complication of rheumatoid arthritis. Decreased levels of RBP-J are linked to the disease and could partly underlie the associated bone loss.

X-ray image of knee joint (Shutterstock).

Bioengineered Compound May Aid in Treating Osteoarthritic Joints

A bioengineered molecule designed to bind together key components found in the fluid that surrounds joint areas may improve lubrication and minimize friction. This could potentially slow the degeneration of cartilage tissue that occurs in knee osteoarthritis.

Enlarged image of muscle fibers.

Protein Linked to Dermatomyositis Found to Have Role in Regenerating Muscle

Many people with a rare muscle disease called dermatomyositis carry antibodies to a protein called T1F1γ, but the proteinís role in normal and diseased muscle has been elusive. New NIAMS research shows that T1F1γ has a role in muscle regeneration.

Skin from an epidermolysis bullosa patient, showing collagen and keratin in color.

Stem Cell-Based Strategies Offer Personalized Approaches For Treating Inherited Skin Disease

Two new studies describe efforts to develop stem cell-based approaches for treating Epidermolysis Bullosa (EB), a rare, genetic skin disease. People with EB have skin so fragile that the slightest friction causes blisters.

Photo of man in pain holding his knee (Shutterstock image).

Long-term Follow-up Data From Large Orthopaedic Studies May Help Guide Clinical Practice

Musculoskeletal conditions like spinal stenosis and anterior cruciate ligament (ACL) tears in the knee affect people of all ages and can be debilitating. Recently reported long-term data provide clinically valuable insights into outcomes associated with treatments.

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Alopecia Areata, Fast Facts
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