Cartilage Biology and Orthopaedics Branch

The Cartilage Biology and Orthopaedics Branch conducts basic and clinical research directed towards understanding the mechanisms regulating cartilage function and the basis of cartilage and orthopaedic diseases, and the development of functional cartilage tissue substitutes. The researchers in the Cartilage Biology and Orthopaedics Branch are using cellular, molecular, and genetic approaches to analyze cartilage development, growth, diseases and aging, as well as applying the emerging technology of mesenchymal stem cell-based tissue engineering for functional cartilage replacement. There are three interactive research sections within the Branch: Developmental Biology, Orthopaedics, and Tissue Engineering.

Selected Publications

Jackson WM, Aragon AB, Onodera J, Koehler SM, Ji Y, Bulken-Hoover JD, Vogler JA, Tuan RS, Nesti LJ. Cytokine expression in muscle following traumatic injury. J Orthop Res. 2011 Mar 30. PubMed Icon

Jackson WM, Lozito T, Djouad F, Kuhn NZ, Nesti LJ, Tuan RS. Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med. 2010 Dec 3. PubMed Icon

Jackson WM, Nesti LJ, Tuan RS. Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells. Expert Opin Biol Ther. 2010 Apr;10(4):505-17. PubMed Icon

Baechler MF, Groth AT, Nesti LJ, Martin BD. Soft tissue management of war wounds to the foot and ankle. Foot Ankle Clin. 2010 Mar;15(1):113-38. PubMed Icon

Jackson WM, Aragon AB, Bulken-Hoover JD, Nesti LJ, Tuan RS. Putative heterotopic ossification progenitor cells derived from traumatized muscle. J Orthop Res. 2009 Dec;27(12):1645-51. PubMed Icon

See extended list of publications


Reviewed September 24, 2012