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Centers of Research Translation
Updated December 2012
The Centers of Research Translation (CORT) (P50) encompass a multidisciplinary team approach to a disease targeted translational theme within the NIAMS mission. A minimum of three highly meritorious translational research projects, as well as an administrative core, form the basic elements of each CORT. The projects listed below were funded through RFA-AR-11-002.
CENTER FOR RESEARCH TRANSLATION at Boston University Medical Campus
Principal Investigator: Lafyatis, Robert A.
Project start date: September 2011
Funded through: August 2016
Current subprojects:
- Biomarkers of the Pulmonary Complications of Scleroderma: The SSc-PAH and SSc-ILD Phenotypes
- The Role of Endoplasmic Reticulum Stress in Systemic Scleroderma
- Biomarkers of Disease Activity and Progression in Systemic Sclerosis
- Clinical Core
- Microarray Core
CENTER FOR RESEARCH TRANSLATION OF SYSTEMIC EXON-SKIPPING IN MUSCULAR DYSTROPHY at the Children's Research Institute in Washington, D.C.
Principal Investigator: Hoffman, Eric P.
Project start date: September 2011
Funded through: August 2016
Current subprojects:
- RNA Fidelity and Protein Function of Becker-like In-frame Deletions
- Optimization of Antisense Oligonucleotide Drugs to Exons 45, 51 and 53
- Becker Muscular Dystrophy: A Natural History Study to Predict Efficacy of Exon Skipping
- In Vitro and In Vivo Functional Assays Core
- Molecular Diagnostics and Cell Banking Core
OKLAHOMA SJOGREN'S SYNDROME CENTER OF RESEARCH TRANSLATION at the Oklahoma Medical Research Foundation
Principal Investigator: Sivils, Kathy L.
Project start date: July 2011
Funded through: June 2016
Current subprojects:
- Integrative Genomics in Primary Sjogren’s Syndrome
- Novel Approach to T Cell Specificity in Sjogren’s Syndrome
- Pathogenic B Cells in Sjogren’s Syndrome
- Data Analysis and Bioinformatics Core
- Clinical Core
CENTER OF RESEARCH TRANSLATION at the University of Alabama at Birmingham
Principal Investigators: Saag, Kenneth G. and Bridges, S. Louis
Project start date: September 2012
Funded through: August 2017
Current subprojects:
- The Effects of Urate Lowering Therapy on Inflammation, Endothelial Function, and Blood Pressure
- Determinants of Achieving Target Serum Urate in Gout and Safety of Gout Treatments
- A Novel Centralized ‘Virtual’ Gout Clinic for Chronic Gout Management
IMMUNOBIOLOGY OF LEPROSY Center of Research Translation at the University of California, Los Angeles
Principal Investigator: Modlin, Robert L.
Project start date: August 2012
Funded through: July 2017
Current subprojects:
- Differential Induction and Antimicrobial Function of Interferons in Leprosy
- Interferon Inducible Gene Programs in Leprosy
- Transcriptional Networks in the Immune Response to Leprosy
- Vitamin D Metabolism in Leprosy
- Bioinformatics Core
TRANSLATION OF QUANTITATIVE IMAGING IN OSTEOARTHRITIS at the University of California, San Francisco
Principal Investigators: Majumdar, Sharmila and Lane, Nancy E.
Project start date: August 2011
Funded through: July 2016
Current subprojects:
- Characterization of Cartilage Using Magnetic Resonance Imaging and Kinematics in Hip Osteoarthritis
- Quantitative Magnetic Resonance Imaging and Gait Analysis for Anterior Cruciate Ligament-Injured and Reconstructed Knees
- T2 Relaxation Time in the Osteoarthritis Initiative (OAI) Normal, Incidence and Progression Cohorts
- Risk Factors and Health Impact of Lateral Compartment Knee Osteoarthritis: The Osteoarthritis Initiative
- Imaging and Data Analysis Core
- Human Performance and Functional Testing Core
INNOVATIONS TO ASSESS AND FORESTALL POST-TRAUMATIC OSTEOARTHRITIS Center of Research Translation at the University of Iowa
Principal Investigator: Buckwalter, Joseph A.
Project start date: September 2007
Funded through: June 2017
Current subprojects:
- Targeting the Origins of Inflammation in Post-Traumatic Osteoarthritis
- Establishing Treatments and Diagnostic Tools for Post-Traumatic Osteoarthritis In Vivo
- Diagnosing and Preventing Elevated Joint Contact Stress to Avert Post-Traumatic Osteoarthritis
- Joint Trauma Biomarkers Core
- Biomechanics and Imaging Core
TRANSLATING MOLECULAR SIGNAL PATHWAYS TO ORTHOPAEDIC TRAUMA CARE at the University of Rochester
Principal Investigator: O'Keefe, Regis J.
Project start date: August 2006
Funded through: July 2017
Current subprojects:
