Osteoarthritis Initiative

December 1999 (historical)

Osteoarthritis Initiative Steering Group

Agenda

The Osteoarthritis Initiative-A Public-Private
Research Collaboration
February 28-29, 2000
Lister Hill Auditorium


Monday, February 28, 2000

8:00 a.m.  
Welcome and Introductions Stephen Katz, M.D., Ph.D.
Director
National Institute of Arthritis and Musculoskeletal and Skin Diseases

Richard Hodes, M.D.
Director; National Institute on Aging
8:15 a.m.  
Presentation of Overall Focus and Structural Guidelines of the Osteoarthritis Initiative and Charge for Meeting Stephen Katz, M.D., Ph.D.
Director
National Institute of Arthritis and Musculoskeletal and Skin Diseases

Joan McGowan, Ph.D.
Chief, Musculoskeletal Disease Branch
National Institute of Arthritis and Musculoskeletal and Skin Diseases
9:00 a.m.  
BIOCHEMICAL MARKERS
Moderator



Presentation of Biomarkers "White Paper"

James Witter, M.D., Ph.D.
Medical Officer
Food and Drug Administration

A. Robin Poole, Ph.D., D.Sc.
Professor, Department of Surgery
Director, Joint Disease Laboratory
McGill University
9:45 a.m.  
Perspectives on Biomarker Development and Use David Eyre, Ph.D.
Burgess Professor of Orthopaedic Research
University of Washington

Dick Heinegård, M.D., Ph.D.
Professor, Department of Cell and Molecular Biology; University of Lund
10:25 a.m.  
Coffee Break Lobby
10:45 a.m.  
Presentation of "straw" proposals Biomarkers Key Question:
Are there biochemical markers that would allow assessment of response to disease-modifying therapies?
Thasia Woodworth, M.D.
Senior Associate Director
Pfizer Central Research
11:45 a.m.  
IMAGING
Moderator



Perspectives and Considerations on Imaging Techniques

Randall Stevens, M.D.
Director, Clinical Science
Hoffman-LaRoche

Laurance Hall, Ph.D.
Herchel Smith Laboratory for Medicinal Chemistry
Cambridge University

Chris Buckland-Wright, Ph.D., D.Sc.
Professor, Department of Applied Clinical Anatomy
School of Biomedical Sciences; King's College
London
12:45 p.m.  
Lunch Lister Hill Cafeteria
1:30 p.m  
Presentation of "straw" proposals Imaging Techniques Key Question: Are structural features of the joint (hip or knee) and associated tissue changes (joint space narrowing and osteophytes) reliable markers of disease or disease progression? Charles Peterfy, M.D., Ph.D.
Chief Scientific Officer
Executive Vice President
Synarc, Inc.
2:15 p.m.  
BIOSTATISTICS
Moderator





Presentation of Biostatistics "White Paper"

Yetunde Taiwo, Ph.D.

Section Head, Late Stage Arthritis Research
Procter & Gamle Pharmaceuticals

Ronald Helms, Ph.D.
Vice President, Statistics; Rho, Inc.
3:00 p.m.  
EPIDEMIOLOGY
Moderator







Presentation of Epidemiology "White Paper"

Kenneth Brandt, M.D.

Professor of Medicine
Head, Rheumatology Division Director, Multipurpose Arthritis Disease Center
Indiana University School of Medicine
Marc Hochberg, M.D., M.P.H. Professor of Medicine and Epidemiology and Preventive Medicine; University of Maryland at Baltimore School of Medicine
3:45 p.m.  
Perspectives on the Status of Current Cohort Studie David Felson, M.D.
Boston University Arthritis Center; Boston, MA
Michael Nevitt, Ph.D., M.P.H. Department of Epidemiology and Biostatistics
University of California, San Francisco
4:15 p.m.  
Coffee Break Lobby
4:30 p.m.  
Presentation of "straw" proposals Epidemiology/Cohort Selection Key Question:
Will the initiative be a single study or a composite of several studies to address needed areas of biomarker research in osteoarthritis?
Leena Sharma, M.D.
Assistant Professor of Medicine Division of Rheumatology Northwestern University
5:15 p.m.  
ADMINISTRATION
Moderator





Presentation of "straw" proposals
Initial Presentation of Administrative Model/Structure

Gregory Downing, D.O., Ph.D.
Health Science Policy Advisor
Office of Science Policy, Office of the Director
National Institutes of Health

Stephen Stimpson, Ph.D.
Exploratory Discovery Head
Musculoskeletal Diseases
Glaxo Wellcome Inc.
6:15 p.m.  
Adjourn for Reception  
DoubleTree Hotel Rockville
6:30 p.m  
Reception Plaza I Room
8:00 p.m.  
Open Forums
Feedback and Discussion:
Session 1 - Biomarkers
Session 2 - Imaging
Session 3 - Epidemiology


Randolph Room
Regency Room
Plaza II Room
10:00 p.m.  
Adjourn until Tuesday morning  
Tuesday, February 29, 2000
Lister Hill Auditorium
8:00 a.m.  
CLINICAL END POINTS
Moderator




Perspectives on Clinical End Points for Osteoarthritis: Two Presentations With Discussion

Virginia Kraus, M.D.
Assistant Professor; Division of
Rheumatology; Department of Medicine
Duke University

Deborah Freund, Ph.D.
Vice Chancellor and Provost
Syracuse University
Representing the Arthritis Foundation

Nicholas Bellamy, M.D., M.Sc.
Director, Centre of National Research on Disability and Rehabilitation Medicine
Faculty of Health Sciences
The University of Queensland
9:30 a.m.  
Summary of Biomarkers Session and Consensus Thasia Woodworth, M.D.
Senior Associate Director
Pfizer Central Research

James Witter, M.D., Ph.D.
Medical Officer
Food and Drug Administration
10:15 a.m.  
Coffee Break Lobby
10:30 a.m.  
Summary of Imaging Session and Consensus Charles Peterfy, M.D.
Chief Scientific Officer
Executive Vice President
Synarc, Inc.

Randall Stevens, M.D.
Director, Clinical Science
Hoffman-LaRoche
11:15 a.m.  
Summary of Epidemiology Session and Consensus Stefan Lohmander, M.D., Ph.D.
Professor, Department of Orthopedics
University Hospital
University of Lund

Kenneth Brandt, M.D.
Professor of Medicine
Head, Rheumatology Division
Director, Multipurpose Arthritis Disease Center
Indiana University School of Medicine
12:00 p.m.  
Lunch Lister Hill Cafeteria
1:00 p.m.  
Summary of Administrative Session and Consensus Stephen Stimpson, Ph.D.
Exploratory Discovery Head
Musculoskeletal Diseases
Glaxo Wellcome Inc.

Gregory Downing, D.O., Ph.D.
Health Science Policy Advisor
Office of Science Policy, Office of
the Director; National Institutes of Health
1:45 p.m.  
Next Steps Stephen Katz, M.D., Ph.D.
Director
National Institute of Arthritis and Musculoskeletal and Skin Diseases

Richard Hodes, M.D.
Director
National Institute on Aging
2:05 p.m.  
Overall Initiative Proposal
Moderator





Presentation of "straw" proposals for InitiativeStatement, Clarification of Research Questions for Osteoarthritis Initiative

Gayle Lester, Ph.D.

Project Coordinator; Osteoarthritis Initiative
National Institute of Arthritis and Musculoskeletal and Skin Disease

Stefan Lohmander, M.D., Ph.D.
Professor, Department of Orthopedics
University Hospital
University of Lund
2:45 p.m.  
Coffee Break Lobby
3:00 p.m.  
Discussion and Consensus on Proposals for Osteoarthritis Initiative Gayle Lester, Ph.D.
Project Coordinator
Osteoarthritis Initiative
National Institute of Arthritis and Musculoskeletal and Skin Disease

Stefan Lohmander, M.D., Ph.D.
Professor, Department of Orthopedics
University Hospital
University of Lund
4:00 p.m.  
Adjournment