The NIH defines a clinical trial as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include placebo or other control) to evaluate the effects of those interventions on health-related biomedical or behavioral outcomes. Clinical trials range from small, first-in-human, tolerability or exploratory studies, to larger trials of efficacy or effectiveness. The NIAMS clinical trials program is designed to support the spectrum of such studies with funding mechanisms tailored to different levels of complexity and risk.

Preparing to Apply for a Clinical Trial

Plan your clinical research grant that meets NIAMS and NIH requirements.

Registering with ClinicalTrials.gov

Follow the steps to register your clinical research grant.

Patient Research Registries

Leverage patient registry data for your clinical research study.

Clinical Trial Policies, Guidelines, and Templates

Understand the NIAMS, NIH, and federal policies and guidelines.

Clinical Research Grants

Get answers to common questions about the clinical research grant process.