Sartorelli Lab

Germ Cell Formation in Mice Relies on RNA Clearance Mechanism

All of our cells, be they skin, muscle or bone, contain the same genetic material. Yet these cells appear different and have unique functions. Decades of research have revealed that the distinctions arise during development as a result of differential gene expression. Now, new work has revealed clues about how this process occurs.
Alessandra Pasut, Ph.D., is a postdoctoral fellow in the Laboratory of Muscle Stem Cells and Gene Regulation at the National Institute of Allergy and Infectious Diseases (NIAMS).
Vittorio Sartorelli, M.D., is leading a team of scientists who are working to better understand the cellular and molecular mechanisms regulating specification, differentiation, and regeneration of skeletal muscle cells.
Dr. Benhalevy’s interests lie in how cellular pathways are affected by the spatial organization of organelles and molecules. He is studying the mechanisms that rely on RNA localization and RNA-protein interactions.
Xiantao Wang uses photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) to identify RNA binding protein target sites on a genome-wide scale and prepare a small RNA cDNA library.

Protein Linked to Dermatomyositis Found to Have Role in Regenerating Muscle

Many people with a rare muscle disease called dermatomyositis carry antibodies to a protein called T1F1γ, but the protein’s role in normal and diseased muscle has been elusive. Now, a study led by investigators at the NIH’s National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) provides some insight by showing that T1F1γ has a role in muscle regeneration.
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