전신 홍반성 루푸스(루푸스)란 무엇인가요? 전신 홍반성 루푸스(루푸스)는 다음과 같은 부위를 포함하여 몸의 여러 부분을 침범할 수 있는 만성(지속성) 자가면역 질환입니다. 피부. 관절. 심장. 폐. 신장. 뇌. 루푸스는 감염과 질환으로부터 몸을 보호하는 데 도움이 되는 면역체계가 자신의 조직을 공격할 때 일어납니다. 경우에 따라서, 이 공격은 염증과 영구적인 조직 손상을 일으킵니다. 루푸스가 있는 경우에는 아플 때(발적)와 건강한 때(증상 소멸)가 있을 수 있습니다. 루푸스 발적은 경증에서 중증까지 있을 수 있으며 패턴을 따르지 않습니다. 그러나 루푸스를 가진 많은 사람들이 치료를 통해 이 질환을 관리할 수 있습니다.
아토피 피부염은 무엇인가요? 흔히 습진으로 불리는 아토피 피부염은 만성(지속성) 질환으로 피부를 극도로 가렵게 만들어 부풀게 하고 염증을 일으킵니다. 긁으면 다음과 같은 증상이 생기게 됩니다. 발적. 부기. 균열. “삼출성”의 투명한 액체. 가피(딱지). 인설. 대부분의 경우, 질환이 악화되어 발적이라고 불리는 시기와 이에 이어 피부가 개선되거나 증상이 완전히 사라지는 관해(증상 소실)라고 불리는 시기가 있습니다. 아토피 피부염은 흔한 질환으로 누구나 생길 수 있습니다. 그러나 보통, 소아기에 시작합니다. 아토피 피부염은 사람 간에는 전파되지 않습니다. 아토피 피부염을 일으키는 원인은 모릅니다. 증상이 얼마나 심한가에 따라 다르지만, 아토피 피부염과 함께 생활하는 것은 힘들 수 있습니다. 그러나 치료는 증상을 관리하는 데 도움이 될 수 있습니다.
Led by Dr. Mariana Kaplan, the branch studies autoimmune diseases, like lupus and rheumatoid arthritis, seeking treatments and improved outcomes.
This public-private partnership seeks to develop new ways of identifying and validating promising biological targets for diagnostics and drug development.
Dr. Lewandowski leads a team of scientists studying the genetics of early-onset systemic lupus erythematosus patients in populations around the globe. Her research focuses on genetic drivers of severe disease and inflammation in diverse cohorts worldwide.
Sarthak Gupta, M.D., conducts research to better understand sex differences in neutrophil biology. He is also an investigator on several ongoing clinical trials in systemic lupus erythematosus at the NIH.
Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.
What is fibromyalgia? Fibromyalgia is a long-lasting disorder that causes pain and tenderness throughout the body. It also can cause you to feel overly tired (fatigue) and have trouble sleeping. Doctors do not fully understand what causes fibromyalgia, but people with the disorder are more sensitive to pain.
What is atopic dermatitis? Atopic dermatitis, often called eczema, is a chronic (long-lasting) disease that causes the skin to become inflamed and irritated, making it extremely itchy. Scratching leads to: Redness. Swelling. Cracking. “Weeping” clear fluid. Crusting. Scaling. In most cases, there are times when the disease is worse, called flares, followed by times when the skin improves or clears up entirely, called remissions. Atopic dermatitis is a common condition, and anyone can get the disease. However, it usually begins in childhood. Atopic dermatitis cannot be spread from person to person. No one knows what causes atopic dermatitis. Depending on
What is systemic lupus erythematosus (lupus)? Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body, including the: Skin. Joints. Heart. Lungs. Kidneys. Brain. Lupus happens when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues. This attack causes inflammation and, in some cases, permanent tissue damage. If you have lupus, you may have times of illness (flares) and times of wellness (remission). Lupus flares can be mild to serious, and they do not follow a pattern. However, with treatment, many people with lupus
What is rosacea? Rosacea (ro-ZAY-she-ah) is a long-term skin condition that causes reddened skin and a rash, usually on the nose and cheeks. It may also cause eye problems.
What is ichthyosis? Ichthyosis is a group of skin disorders. It leads to dry, itchy skin that appears scaly, rough, and red. The symptoms can range from mild to severe. Ichthyosis can affect only the skin, but sometimes the disease can affect internal organs, too.
Research supported by the Accelerating Medicines Partnership (AMP) on Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) provides new insights into tissue damage for these autoimmune conditions. Findings include the identification of novel molecular signatures related to immune system signaling in kidney cells that may reflect their active role in disease process; molecular targets, including specific white blood cells, for potential treatment in lupus nephritis; and specific types of fibroblasts and white blood cells that are involved in rheumatoid arthritis.
Scientists can distinguish between highly similar cell types using cutting-edge laboratory procedures. Using such techniques, IRP researchers have identified a particular variety of cell in a specific stage of its life cycle as a primary culprit behind the autoimmune disease known as lupus.
Known as the “disease with a thousand faces,” systemic lupus erythematosus is a lifelong autoimmune disease with a wide range of symptoms and signs—fatigue, fever, joint pain, facial rash and skin lesions, shortness of breath, and more. It may develop suddenly or slowly and be mild or severe, with people affected going through periods of flare up and remission of their symptoms.
Human skin is home to diverse ecosystems including bacteria, viruses, and fungi. These microbial communities comprise hundreds of species and are collectively known as the skin microbiome.
Researchers published a proof-of-principle paper in the journal Science Immunology demonstrating just how precision medicine for inflammatory skin rashes might work.
A treatment for severe skin inflammation that works well in lean mice made the condition worse in obese mice because of immune-cell changes associated with obesity.
Researchers have identified a potential treatment to reduce the risk of cardiovascular disease in people with systemic lupus erythematosus (SLE), a chronic autoimmune disease.