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Scientists Pinpoint Traitorous Immune Cells in Lupus

https://www.niams.nih.gov/scientists-pinpoint-traitorous-immune-cells-lupus

Scientists can distinguish between highly similar cell types using cutting-edge laboratory procedures. Using such techniques, IRP researchers have identified a particular variety of cell in a specific stage of its life cycle as a primary culprit behind the autoimmune disease known as lupus.

Systemic Lupus Erythematosus (Lupus)

https://www.niams.nih.gov/health-topics/lupus

What is systemic lupus erythematosus (lupus)? Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body, including the: Skin. Joints. Heart. Lungs. Kidneys. Brain. Lupus happens when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues. This attack causes inflammation and, in some cases, permanent tissue damage. If you have lupus, you may have times of illness (flares) and times of wellness (remission). Lupus flares can be mild to serious, and they do not follow a pattern. However, with treatment, many people with lupus

Fibromyalgia

https://www.niams.nih.gov/health-topics/fibromyalgia

What is fibromyalgia? Fibromyalgia is a long-lasting disorder that causes pain and tenderness throughout the body. It also can cause you to feel overly tired (fatigue) and have trouble sleeping. Doctors do not fully understand what causes fibromyalgia, but people with the disorder are more sensitive to pain.

Psoriasis

https://www.niams.nih.gov/health-topics/psoriasis

What is psoriasis? Psoriasis is a chronic (long-lasting) disease in which the immune system works too much, causing patches of skin to become scaly and inflamed. Most often, psoriasis affects the: Scalp. Elbows. Knees. The symptoms of psoriasis can sometimes go through cycles, flaring for a few weeks or months followed by times when they subside (or go into remission). If you have psoriasis, you may have a higher risk of getting other serious conditions, including: Psoriatic arthritis. Heart attack or stroke. Mental health problems, such as low self-esteem, anxiety, and depression.

Systemic Autoimmunity Branch

https://www.niams.nih.gov/labs/kaplan-lab

Led by Dr. Mariana Kaplan, the branch studies autoimmune diseases, like lupus and rheumatoid arthritis, seeking treatments and improved outcomes.

NIAMS Involvement in the Accelerating Medicines Partnership® (AMP®)

https://www.niams.nih.gov/grants-funding/funded-research/accelerating-medicines

This public-private partnership seeks to develop new ways of identifying and validating promising biological targets for diagnostics and drug development.

A More Precise Way to Knock Out Skin Rashes

https://www.niams.nih.gov/more-precise-way-knock-out-skin-rashes

Researchers published a proof-of-principle paper in the journal Science Immunology demonstrating just how precision medicine for inflammatory skin rashes might work.

Roundtable Discussion on Lupus with Congresswoman Lee

https://www.niams.nih.gov/about/meetings-events/visits/roundtable-discussion-lupus-congresswoman-lee

Video of a Facebook Live discussion on lupus research, treatment, and care, moderated by Rev. Cheryl Ward and featuring experts in the field.

Understanding Autoimmune Diseases

https://www.niams.nih.gov/understanding-autoimmune-diseases

Sometimes, your immune system makes mistakes. If it sees your body’s healthy cells as a threat, it may attack them. This can cause an autoimmune disorder.

FDA Approves First Systemic Treatment for Alopecia Areata

https://www.niams.nih.gov/fda-approves-first-systemic-treatment-alopecia-areata

The FDA approved Olumiant (baricitinib) oral tablets to treat adult patients with severe alopecia areata. The action marks the first FDA approval of a systemic treatment (i.e. treats the entire body rather than a specific location) for alopecia areata.

A Biological Betrayal

https://www.niams.nih.gov/biological-betrayal

Dr. Kaplan has studied a number of autoimmune diseases, from rheumatoid arthritis to vasculitis, but most of her efforts have been focused on what she calls “the poster child” for autoimmune diseases: systemic lupus erythematosus (SLE), more commonly referred to as ‘lupus.’

Laura B. Lewandowski, M.S., M.D.

https://www.niams.nih.gov/about/directory/laura-b-lewandowski-ms-md

Dr. Lewandowski leads a team of scientists studying the genetics of early-onset systemic lupus erythematosus patients in populations around the globe. Her research focuses on genetic drivers of severe disease and inflammation in diverse cohorts worldwide.

Sarthak Gupta, M.D.

https://www.niams.nih.gov/about/directory/sarthak-gupta-md

Sarthak Gupta M.D., is a Rheumatologist and an Assistant Research Physician in Lupus clinical trials.

Casting the NET Wide: How Neutrophils Shape Chronic Autoimmune and Inflammatory Diseases

https://www.niams.nih.gov/casting-net-wide-how-neutrophils-shape-chronic-autoimmune-and-inflammatory-diseases

Known as the “disease with a thousand faces,” systemic lupus erythematosus is a lifelong autoimmune disease with a wide range of symptoms and signs—fatigue, fever, joint pain, facial rash and skin lesions, shortness of breath, and more. It may develop suddenly or slowly and be mild or severe, with people affected going through periods of flare up and remission of their symptoms.

New treatment shows promise in reducing the risk of cardiovascular disease in people with lupus

https://www.niams.nih.gov/newsroom/spotlight-on-research/new-treatment-shows-promise-reducing-risk-cardiovascular-disease

Researchers have identified a potential treatment to reduce the risk of cardiovascular disease in people with systemic lupus erythematosus (SLE), a chronic autoimmune disease.

Exercise Energizes Patients With Autoimmune Disease

https://www.niams.nih.gov/exercise-energizes-patients-autoimmune-disease

Recently, a small IRP study showed that exercise training can help reduce the debilitating fatigue that often accompanies the autoimmune disease known as lupus, and also illuminated some of the underlying mechanisms that may lead to those benefits.

Alopecia Areata

https://www.niams.nih.gov/health-topics/alopecia-areata

What is alopecia areata? Alopecia areata is a disease that causes hair loss. In alopecia areata, the immune system attacks the structures in skin that form hair (hair follicles). Alopecia areata usually affects the head and face, though hair can be lost from any part of the body. Hair typically falls out in small, round patches about the size of a quarter. In some cases, hair loss is more extensive.

Rosacea

https://www.niams.nih.gov/health-topics/rosacea

What is rosacea? Rosacea is a long-term skin condition that causes reddened skin and a rash, usually on the nose and cheeks. It may also cause eye problems.

Mariana J. Kaplan, M.D.

https://www.niams.nih.gov/about/directory/mariana-j-kaplan-md

Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.