Blocking enzyme inhibits arthritis progression in mice
https://www.niams.nih.gov/blocking-enzyme-inhibits-arthritis-progression-mice
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Long-running fractures study doubles as a bountiful women’s health data source
https://www.niams.nih.gov/long-running-fractures-study-doubles-bountiful-womens-health-data-source
NIH Offers Web-Based Tool to Study Gene Expression in Human Neutrophils
NIH scientists developed and recently released a free, online data query tool called NeutGX. Researchers around the world can use NeutGX to explore the genetic basis of neutrophil-mediated inflammation in autoimmune diseases, cancer, infectious diseases and other conditions.
Osteoporosis
https://www.niams.nih.gov/health-topics/osteoporosis
What is osteoporosis? Osteoporosis is a disease that causes bones to become weak and brittle. This increases your risk of broken bones (fractures). Osteoporosis is a “silent” disease because you may not have symptoms. You may not even know you have the disease until you break a bone. Breaks can occur in any bone but happen most often in: Hip bones. Vertebrae in the spine. Wrist. You can take steps to help prevent osteoporosis and broken bones by: Doing weight-bearing exercises, such as walking or dancing, and lifting weights. Not drinking too much alcohol. Quitting smoking, or not starting if
Scleroderma
https://www.niams.nih.gov/health-topics/scleroderma
What is scleroderma? Scleroderma is an autoimmune connective tissue and rheumatic disease that causes inflammation in the skin and other areas of the body. This inflammation leads to patches of tight, hard skin. Scleroderma involves many systems in your body. A connective tissue disease is one that affects tissues such as skin, tendons, and cartilage. There are two major types of scleroderma: Localized scleroderma only affects the skin and the structures directly under the skin. Systemic scleroderma, also called systemic sclerosis, affects many systems in the body. This is the more serious type of scleroderma and can damage your blood
Arthritis
https://www.niams.nih.gov/health-topics/arthritis
What is arthritis? "Arthritis" literally means joint inflammation. Although joint inflammation is a symptom or sign rather than a specific diagnosis, the term arthritis is often used to refer to any disorder that affects the joints. Joints are places where two bones meet, such as your elbow or knee. There are different types of arthritis. In some diseases in which arthritis occurs, other organs, such as your eyes, heart, or skin, can also be affected. Fortunately, current treatments allow most people with arthritis to lead active and productive lives.
Systemic Autoimmunity Branch
https://www.niams.nih.gov/labs/kaplan-lab
Led by Dr. Mariana Kaplan, the branch studies autoimmune diseases, like lupus and rheumatoid arthritis, seeking treatments and improved outcomes.
Cutaneous Development and Carcinogenesis Section
https://www.niams.nih.gov/labs/brownell-lab
Led by Dr. Isaac Brownell, the Cutaneous Development and Carcinogenesis Section studies the signaling pathways such as Hedgehog signaling that regulate the development and maintenance of normal skin and the changes in these signals that occur during the formation of skin cancer
What Our Proteins Can Tell Us About Autoimmune Diseases
https://www.niams.nih.gov/what-our-proteins-can-tell-us-about-autoimmune-diseases
Adeline Chin, a postbaccalaureate research fellow, is searching for proteins present at abnormally high or low levels in the blood of kids with a rare autoimmune illness.
Polymyalgia Rheumatica and Giant Cell Arteritis
https://www.niams.nih.gov/health-topics/polymyalgia-rheumatica-giant-cell-arteritis
What are polymyalgia rheumatica and giant cell arteritis? Polymyalgia rheumatica and giant cell arteritis are closely linked inflammatory disorders. Some people have one of the disorders while others develop both of them. Polymyalgia rheumatica causes muscle pain and stiffness in the shoulders, upper arms, hip area, and sometimes the neck. Giant cell arteritis causes inflammation of arteries, especially those on each side of the head, scalp, and the aorta (the large artery that carries blood from the heart) and its main branches. The main symptoms of this disorder are: Headaches. Scalp tenderness. Jaw pain. Problems with your eyes, which may
Discussing Bone, Muscle, Skin, & Autoimmune Diseases: Info for American Indians, Alaska Natives - audio
A conversation between Dr. David R. Wilson, director of the NIH Tribal Health Research Office, and Dr. Lindsey A. Criswell, director of NIAMS, about information and resources for American Indians and Alaska Natives related to bone, muscle, skin, and autoimmune diseases.
NIAMS, NIH Seek to Better Understand Arthritis in Native American Communities
The recent observance in May of National Arthritis Awareness Month offered us a chance to reflect on a sizable component of the NIAMS mission area. Arthritis impacts the lives of nearly 60 million Americans. However, a recent conversation with David Wilson, Ph.D., director of NIH’s Tribal Health Research Office, reminded me that arthritis hits some communities harder than others.
Recharging cartilage after knee damage
https://www.niams.nih.gov/recharging-cartilage-after-knee-damage
NIBIB-funded researchers are developing an implantable, biodegradable film that helps to regenerate the native cartilage at the site of damage. Their study, performed in rabbits, could be an initial, important step in the establishment of a new treatment for this common condition, osteoarthritis.
Understanding Autoimmune Diseases
https://www.niams.nih.gov/understanding-autoimmune-diseases
Sometimes, your immune system makes mistakes. If it sees your body’s healthy cells as a threat, it may attack them. This can cause an autoimmune disorder.
Acne
https://www.niams.nih.gov/health-topics/acne
What is acne? Acne is a common skin condition that happens when hair follicles under the skin become clogged. Oil and dead skin cells plug the pores, and outbreaks of lesions (often called pimples or zits) can happen. Most often, the outbreaks occur on the face but can also appear on the back, chest, and shoulders. For most people, acne tends to go away by the time they reach their thirties, but some people in their forties and fifties continue to have this skin problem.
Carmelo Carmona-Rivera, Ph.D.
https://www.niams.nih.gov/about/directory/carmelo-carmona-rivera-phd
Dr. Carmelo Carmona-Rivera studies the role of post-translational modifications such as citrullination, carbamylation, and others in the pathogenesis of rheumatoid arthritis, hidradenitis suppurativa, and other autoinflammatory/autoimmune conditions.
Workshop Explores Strategies to Tackle Health Disparities in Osteoarthritis
https://www.niams.nih.gov/workshop-explores-strategies-tackle-health-disparities-osteoarthritis
A recent 2-day NIH workshop aimed to better understand health disparities in caring for and treating people with osteoarthritis (OA) and the role played by social determinants of health. NIAMS, NIA and NIMHD sponsored the event.
Autoimmune response found in many with COVID-19
https://www.niams.nih.gov/autoimmune-response-found-many-covid-19
Exercise Energizes Patients With Autoimmune Disease
https://www.niams.nih.gov/exercise-energizes-patients-autoimmune-disease
Recently, a small IRP study showed that exercise training can help reduce the debilitating fatigue that often accompanies the autoimmune disease known as lupus, and also illuminated some of the underlying mechanisms that may lead to those benefits.