Site Search | NIAMS

Enter a phrase above to search files and articles within the site.

Typically materials that are more than 5 years old will be archived

Displaying 1 - 20 of 42 results

Scientists Pinpoint Traitorous Immune Cells in Lupus

https://www.niams.nih.gov/scientists-pinpoint-traitorous-immune-cells-lupus

Scientists can distinguish between highly similar cell types using cutting-edge laboratory procedures. Using such techniques, IRP researchers have identified a particular variety of cell in a specific stage of its life cycle as a primary culprit behind the autoimmune disease known as lupus.

Scleroderma Genomics and Health Disparities Unit

https://www.niams.nih.gov/labs/scleroderma-genomics-and-health-disparities-lab

The Scleroderma Genomics and Health Disparities Unit is focused on unraveling genetic risk by using genomic technologies and dissecting the mechanisms of transcriptional regulation in order to comprehend autoimmune, fibrotic, and health disparity conditions.

Lupus Genomics and Global Health Disparities Unit

https://www.niams.nih.gov/labs/lewandowski-lab

Dr. Lewandowski leads a team of scientists studying systemic lupus erythematosus patients in populations around the globe. Her research focuses on genetic drivers of severe disease and inflammation in diverse cohorts worldwide.

Systemic Lupus Erythematosus (Lupus)

https://www.niams.nih.gov/health-topics/lupus

What is systemic lupus erythematosus (lupus)? Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body, including the: Skin. Joints. Heart. Lungs. Kidneys. Brain. Lupus happens when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues. This attack causes inflammation and, in some cases, permanent tissue damage. If you have lupus, you may have times of illness (flares) and times of wellness (remission). Lupus flares can be mild to serious, and they do not follow a pattern. However, with treatment, many people with lupus

Systemic Autoimmunity Branch

https://www.niams.nih.gov/labs/kaplan-lab

Led by Dr. Mariana Kaplan, the branch studies autoimmune diseases, like lupus and rheumatoid arthritis, seeking treatments and improved outcomes.

NIAMS Involvement in the Accelerating Medicines Partnership® (AMP®)

https://www.niams.nih.gov/grants-funding/funded-research/accelerating-medicines

This public-private partnership seeks to develop new ways of identifying and validating promising biological targets for diagnostics and drug development.

Roundtable Discussion on Lupus with Congresswoman Lee

https://www.niams.nih.gov/about/meetings-events/visits/roundtable-discussion-lupus-congresswoman-lee

Video of a Facebook Live discussion on lupus research, treatment, and care, moderated by Rev. Cheryl Ward and featuring experts in the field.

Understanding Autoimmune Diseases

https://www.niams.nih.gov/understanding-autoimmune-diseases

Sometimes, your immune system makes mistakes. If it sees your body’s healthy cells as a threat, it may attack them. This can cause an autoimmune disorder.

A Biological Betrayal

https://www.niams.nih.gov/biological-betrayal

Dr. Kaplan has studied a number of autoimmune diseases, from rheumatoid arthritis to vasculitis, but most of her efforts have been focused on what she calls “the poster child” for autoimmune diseases: systemic lupus erythematosus (SLE), more commonly referred to as ‘lupus.’

Laura B. Lewandowski, M.S., M.D.

https://www.niams.nih.gov/about/directory/laura-b-lewandowski-ms-md

Dr. Lewandowski leads a team of scientists studying the genetics of early-onset systemic lupus erythematosus patients in populations around the globe. Her research focuses on genetic drivers of severe disease and inflammation in diverse cohorts worldwide.

Workshop Explores Strategies to Tackle Health Disparities in Osteoarthritis

https://www.niams.nih.gov/workshop-explores-strategies-tackle-health-disparities-osteoarthritis

A recent 2-day NIH workshop aimed to better understand health disparities in caring for and treating people with osteoarthritis (OA) and the role played by social determinants of health. NIAMS, NIA and NIMHD sponsored the event.

Sarthak Gupta, M.D.

https://www.niams.nih.gov/about/directory/sarthak-gupta-md

Sarthak Gupta M.D., is a Rheumatologist and an Assistant Research Physician in Lupus clinical trials.

Casting the NET Wide: How Neutrophils Shape Chronic Autoimmune and Inflammatory Diseases

https://www.niams.nih.gov/casting-net-wide-how-neutrophils-shape-chronic-autoimmune-and-inflammatory-diseases

Known as the “disease with a thousand faces,” systemic lupus erythematosus is a lifelong autoimmune disease with a wide range of symptoms and signs—fatigue, fever, joint pain, facial rash and skin lesions, shortness of breath, and more. It may develop suddenly or slowly and be mild or severe, with people affected going through periods of flare up and remission of their symptoms.

New treatment shows promise in reducing the risk of cardiovascular disease in people with lupus

https://www.niams.nih.gov/newsroom/spotlight-on-research/new-treatment-shows-promise-reducing-risk-cardiovascular-disease

Researchers have identified a potential treatment to reduce the risk of cardiovascular disease in people with systemic lupus erythematosus (SLE), a chronic autoimmune disease.

Exercise Energizes Patients With Autoimmune Disease

https://www.niams.nih.gov/exercise-energizes-patients-autoimmune-disease

Recently, a small IRP study showed that exercise training can help reduce the debilitating fatigue that often accompanies the autoimmune disease known as lupus, and also illuminated some of the underlying mechanisms that may lead to those benefits.

Osteogenesis Imperfecta

https://www.niams.nih.gov/health-topics/osteogenesis-imperfecta

What is osteogenesis imperfecta? Osteogenesis imperfecta (OI) is a disease that causes your bones to break (fracture) easily. OI is also called brittle bone disease. Your symptoms may be mild or severe, depending on the type of OI you have.

Pachyonychia Congenita

https://www.niams.nih.gov/health-topics/pachyonychia-congenita

What is pachyonychia congenita? Pachyonychia congenita (PC) is a very rare genetic disorder that affects the skin and nails. Most people have thickened nails and calluses on the bottom of the feet. Painful calluses on the soles can make walking difficult. Because of the pain, some people rely on a cane, crutches, or a wheelchair to help with walking.

Mariana J. Kaplan, M.D.

https://www.niams.nih.gov/about/directory/mariana-j-kaplan-md

Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.

Yongquan Luo, Ph.D.

https://www.niams.nih.gov/about/directory/yongquan-luo-phd

Dr. Luo is a biologist in the Pediatric Translational Research Branch. He is pursuing studies of mutation of gene WHAMM on pathogenesis in axial spondyloarthritis using patient derived hiPSCs and CRISPR/Cas9 technologies.