통풍이란 무엇인가요? 통풍은 관절에 통증과 부종을 일으키는 일종의 관절염이며 보통, 1주 또는 2주 동안 지속하다가 사라지는 발작입니다. 통풍 발작은 흔히 엄지발가락이나 하지에서 시작합니다. 통풍은 혈청 요산염으로 불리는 높은 수치의 물질이 몸안에 축적될 때 일어납니다. 이런 일이 일어나면 바늘 모양의 결정체들이 관절 내부와 주위에 형성됩니다. 이것은 관절의 염증과 관절염을 초래합니다. 그러나 혈청 요산염 수치가 높은 대부분 사람들은 통풍이 생기지 않습니다. 조기 진단, 치료, 그리고 생활양식의 변화를 통해, 통풍은 가장 관리가 가능한 형태의 관절염 중 하나입니다.
류마티스 관절염은 무엇인가요? 류마티스 관절염은 손목, 손, 발, 무릎, 척추 그리고 턱 등 관절에 주로 영향을 미치는 만성(지속성) 질환입니다. 류마티스 관절염은 다음과 같은 증상으로 이어지는 염증을 관절에 일으킵니다. 통증. 부기. 뻣뻣함. 기능 상실. 류마티스 관절염은 면역체계가 건강한 관절 조직을 공격하기 때문에 자가면역질환입니다. 보통, 면역체계는 감염과 질환으로부터 인체를 보호하는 데 도움을 줍니다. 류마티스 관절염은 평소와 달리 피로감을 느끼고, 이따금 열이 나며, 식욕을 상실하는 원인이 될 수 있습니다. 또한 심장, 폐, 혈액, 신경, 눈 그리고 피부에 다른 의학적 문제를 일으킬 수 있습니다. 치료를 통해 이 질환을 가진 사람들은 생산적인 생활을 영위하는 데 도움을 받을 수 있습니다.
This public-private partnership seeks to develop new ways of identifying and validating promising biological targets for diagnostics and drug development.
Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.
Dr. Luo is a biologist in the Pediatric Translational Research Branch. He is pursuing studies of mutation of gene WHAMM on pathogenesis in axial spondyloarthritis using patient derived hiPSCs and CRISPR/Cas9 technologies.
What is gout? Gout is a type of arthritis that causes pain and swelling in your joints, usually as flares that last for a week or two, and then go away. Gout flares often begin in your big toe or a lower limb. Gout happens when high levels of a substance called serum urate build up in your body. When this happens, needle-shaped crystals form in and around the joint. This leads to inflammation and arthritis of the joint. However, many people with high levels of serum urate will not develop gout. With early diagnosis, treatment, and lifestyle changes, gout
What is scoliosis? Scoliosis is a sideways curve of the spine. Children and teens with scoliosis have an abnormal S-shaped or C-shaped curve of the spine. The curve can happen on either side of the spine and in different places in the spine. With treatment, observation, and follow-up with the doctor, most children and teens with scoliosis have normal, active lives.
What is osteogenesis imperfecta? Osteogenesis imperfecta (OI) is a disease that causes your bones to break (fracture) easily. OI is also called brittle bone disease. Your symptoms may be mild or severe, depending on the type of OI you have.
What is Raynaud’s phenomenon? Raynaud’s phenomenon is a condition that causes the blood vessels in the hands and feet to narrow, decreasing blood flow. When this happens, parts of the body—usually the fingers and toes—become cold and numb, and change color (usually, to white or blue). An attack usually happens from exposure to cold or stress.
What is pemphigus? Pemphigus is a rare disease that causes blistering on many parts of the body, including the skin and the inside of the mouth, nose, throat, eyes, and genitals. In pemphigus, the immune system mistakenly attacks cells in the top layer of the skin.
What is fibromyalgia? Fibromyalgia is a long-lasting disorder that causes pain and tenderness throughout the body. It also can cause you to feel overly tired (fatigue) and have trouble sleeping. Doctors do not fully understand what causes fibromyalgia, but people with the disorder are more sensitive to pain.
Research supported by the Accelerating Medicines Partnership (AMP) on Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) provides new insights into tissue damage for these autoimmune conditions. Findings include the identification of novel molecular signatures related to immune system signaling in kidney cells that may reflect their active role in disease process; molecular targets, including specific white blood cells, for potential treatment in lupus nephritis; and specific types of fibroblasts and white blood cells that are involved in rheumatoid arthritis.
What is rheumatoid arthritis? Rheumatoid arthritis (RA) is a chronic (long-lasting) disease that mostly affects joints, such as the wrist, hands, feet, spine, knees, and jaw. In joints, RA causes inflammation that leads to: Pain. Swelling Stiffness. Loss of function. Rheumatoid arthritis is an autoimmune disorder because the immune system attacks the healthy joint tissues. Normally, the immune system helps protect the body from infection and disease. RA may cause you to feel unusually tired, to have occasional fevers, and to have a loss of appetite. It also may cause other medical problems in the heart, lungs, blood, nerves, eyes
An NIH Health Capsule article. Scoliosis is a disease that causes the spine to curve. It can result in an abnormal s-shaped or c-shaped curve. Anyone can get scoliosis. But it’s most common in children age 11 and older.
A recent 2-day NIH workshop aimed to better understand health disparities in caring for and treating people with osteoarthritis (OA) and the role played by social determinants of health. NIAMS, NIA and NIMHD sponsored the event.
Led by Dr. Mariana Kaplan, the branch studies autoimmune diseases, like lupus and rheumatoid arthritis, seeking treatments and improved outcomes.