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Mariana J. Kaplan, M.D.

https://www.niams.nih.gov/about/directory/mariana-j-kaplan-md

Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.

Yongquan Luo, Ph.D.

https://www.niams.nih.gov/about/directory/yongquan-luo-phd

Dr. Luo is a biologist in the Pediatric Translational Research Branch. He is pursuing studies of mutation of gene WHAMM on pathogenesis in axial spondyloarthritis using patient derived hiPSCs and CRISPR/Cas9 technologies.

Gout

https://www.niams.nih.gov/health-topics/gout

What is gout? Gout is a type of arthritis that causes pain and swelling in your joints, usually as flares that last for a week or two, and then go away. Gout flares often begin in your big toe or a lower limb. Gout happens when high levels of a substance called serum urate build up in your body. When this happens, needle-shaped crystals form in and around the joint. This leads to inflammation and arthritis of the joint. However, many people with high levels of serum urate will not develop gout. With early diagnosis, treatment, and lifestyle changes, gout

Osteoarthritis

https://www.niams.nih.gov/health-topics/osteoarthritis

What is osteoarthritis? Osteoarthritis is a joint disease that happens when the tissues in the joint break down over time. It is the most common type of arthritis and is more common in older people. People with osteoarthritis usually have joint pain and, after rest, stiffness (inability to move easily) for a short period of time. The most commonly affected joints include the: Hands (ends of the fingers and at the base and ends of the thumbs). Knees. Hips. Neck. Lower back. Osteoarthritis affects each person differently. For some people, osteoarthritis does not affect day-to-day activities. For others, it causes

Osteogenesis Imperfecta

https://www.niams.nih.gov/health-topics/osteogenesis-imperfecta

What is osteogenesis imperfecta? Osteogenesis imperfecta (OI) is a disease that causes your bones to break (fracture) easily. OI is also called brittle bone disease. Your symptoms may be mild or severe, depending on the type of OI you have.

Fibromyalgia

https://www.niams.nih.gov/health-topics/fibromyalgia

What is fibromyalgia? Fibromyalgia is a long-lasting disorder that causes pain and tenderness throughout the body. It also can cause you to feel overly tired (fatigue) and have trouble sleeping. Doctors do not fully understand what causes fibromyalgia, but people with the disorder are more sensitive to pain.

Machine learning detects early signs of osteoarthritis

https://www.niams.nih.gov/machine-learning-detects-early-signs-osteoarthritis

Recharging cartilage after knee damage

https://www.niams.nih.gov/recharging-cartilage-after-knee-damage

NIBIB-funded researchers are developing an implantable, biodegradable film that helps to regenerate the native cartilage at the site of damage. Their study, performed in rabbits, could be an initial, important step in the establishment of a new treatment for this common condition, osteoarthritis.

Engineered cartilage produces anti-inflammatory drug

https://www.niams.nih.gov/engineered-cartilage-produces-anti-inflammatory-drug

Workshop Explores Strategies to Tackle Health Disparities in Osteoarthritis

https://www.niams.nih.gov/workshop-explores-strategies-tackle-health-disparities-osteoarthritis

A recent 2-day NIH workshop aimed to better understand health disparities in caring for and treating people with osteoarthritis (OA) and the role played by social determinants of health. NIAMS, NIA and NIMHD sponsored the event.

Translational Genetics and Genomics Section

https://www.niams.nih.gov/labs/ombrello-lab

Led by Dr. Michael Ombrello, the section uses genomic approaches to understand the underlying factors of autoinflammatory and rheumatic diseases.

Health Disparities in Osteoarthritis Workshop – July 12-13, 2022

https://www.niams.nih.gov/about/meetings-events/roundtables/health-disparities-osteoarthritis-workshop-july-12-13-2022

Background The Health Disparities in Osteoarthritis (OA) workshop brought together OA investigators with others who have expertise in health disparities to exchange ideas regarding how/why disparities in OA treatment and care exist and how they can be addressed. Panelists and speakers highlighted mechanisms through which behavioral and biomedical science integration can lead to better health in OA. The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Aging (NIA), and National Institute on Minority Health and Health Disparities (NIMHD) sponsored the workshop. It was organized by NIH staff and meeting co-chairs Drs. Arleen F. Brown (University

NIAMS Hosts Roundtable on Regenerative Medicine in Knee OA

https://www.niams.nih.gov/niams-hosts-roundtable-regenerative-medicine-knee-oa

NIAMS held a roundtable discussion (September 2022) focused on regenerative medicine approaches for cartilage preservation and restoration in knee osteoarthritis (OA). Researchers, clinicians and FDA and patient representatives met virtually with NIAMS leadership to discuss where and how the institute could facilitate progress in the field.