통풍이란 무엇인가요? 통풍은 관절에 통증과 부종을 일으키는 일종의 관절염이며 보통, 1주 또는 2주 동안 지속하다가 사라지는 발작입니다. 통풍 발작은 흔히 엄지발가락이나 하지에서 시작합니다. 통풍은 혈청 요산염으로 불리는 높은 수치의 물질이 몸안에 축적될 때 일어납니다. 이런 일이 일어나면 바늘 모양의 결정체들이 관절 내부와 주위에 형성됩니다. 이것은 관절의 염증과 관절염을 초래합니다. 그러나 혈청 요산염 수치가 높은 대부분 사람들은 통풍이 생기지 않습니다. 조기 진단, 치료, 그리고 생활양식의 변화를 통해, 통풍은 가장 관리가 가능한 형태의 관절염 중 하나입니다.
골관절염이란 무엇인가요? 골관절염은 관절 내의 조직이 시간이 지나면서 손상될 때 생기는 관절 질환입니다. 골관절염은 가장 흔한 형태의 관절염이며 노년층에 더 흔합니다. 관절염이 있는 사람들은 보통 관절 통증이 있으며, 휴식 후에 잠시 동안 뻣뻣함(쉽게 움직일 수 없는 상태)을 느낍니다. 가장 흔히 골관절염이 생기는 관절은 다음과 같습니다. (손가락의 끝 부분과, 엄지의 맨 아래 부분과 끝 부분) 무릎. 고관절. 목. 허리 하부. 골관절염은 사람마다 다르게 영향을 미칩니다. 어떤 사람들은 일상 활동에 골관절염의 영향을 받지 않습니다. 어떤 사람들에게는, 골관절염이 심한 통증과 장애의 원인이 됩니다.
Led by Dr. Michael Ombrello, the unit uses genomic approaches to understand the underlying factors of autoinflammatory and rheumatic diseases.
Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.
Dr. Yongquan Luo is a biologist in the Pediatric Translational Research Branch. He is pursuing studies of mutation of gene WHAMM on pathogenesis in Axial spondyloarthritis using patient derived hiPSCs and CRISPR/Cas9 technologies.
What is gout? Gout is a type of arthritis that causes pain and swelling in your joints, usually as flares that last for a week or two, and then go away. Gout flares often begin in your big toe or a lower limb. Gout happens when high levels of a substance called serum urate build up in your body. When this happens, needle-shaped crystals form in and around the joint. This leads to inflammation and arthritis of the joint. However, many people with high levels of serum urate will not develop gout. With early diagnosis, treatment, and lifestyle changes, gout
What is pachyonychia congenita? Pachyonychia congenita (PC) is a very rare genetic disorder that affects the skin and nails. Most people have thickened nails and calluses on the bottom of the feet. Painful calluses on the soles can make walking difficult. Because of the pain, some people rely on a cane, crutches, or a wheelchair to help with walking.
What is psoriatic arthritis? Psoriatic arthritis is a condition that causes swelling and pain in joints and the places where tendons and ligaments attach to bones. Most people who develop psoriatic arthritis already have psoriasis (a skin disease), but a small number have joint pain before the skin rash.
What is osteoarthritis? Osteoarthritis is a joint disease that happens when the tissues in the joint break down over time. It is the most common type of arthritis and is more common in older people. People with osteoarthritis usually have joint pain and, after rest, stiffness (inability to move easily) for a short period of time. The most commonly affected joints include the: Hands (ends of the fingers and at the base and ends of the thumbs). Knees. Hips. Neck. Lower back. Osteoarthritis affects each person differently. For some people, osteoarthritis does not affect day-to-day activities. For others, it causes
What is vitiligo? Vitiligo is a chronic (long-lasting) disorder that causes areas of skin to lose color. When skin cells that make color are attacked and destroyed, the skin turns a milky-white color. No one knows what causes vitiligo, but it may be an autoimmune disease. In people with autoimmune diseases, the immune cells attack the body’s own healthy tissues by mistake, instead of viruses or bacteria. A person with vitiligo sometimes may have family members who also have the disease. There is no cure for vitiligo, but treatment may help skin tone appear more even.
What is scleroderma? Scleroderma is an autoimmune connective tissue and rheumatic disease that causes inflammation in the skin and other areas of the body. This inflammation leads to patches of tight, hard skin. Scleroderma involves many systems in your body. A connective tissue disease is one that affects tissues such as skin, tendons, and cartilage. There are two major types of scleroderma: Localized scleroderma only affects the skin and the structures directly under the skin. Systemic scleroderma, also called systemic sclerosis, affects many systems in the body. This is the more serious type of scleroderma and can damage your blood
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Aging (NIA), and National Institute on Minority Health and Health Disparities (NIMHD) are sponsoring a virtual workshop on Health Disparities in Osteoarthritis on Tuesday, July 12 – Wednesday, July 13, 2022, starting at 11:00 AM (ET) each day. The workshop will focus on combining behavioral and biomedical science to address personal, interpersonal, and societal influences that contribute to health disparities in osteoarthritis. Discussions will cover how understanding these disparities can lead to better health in osteoarthritis. Please visit the NIH Health Disparities in Osteoarthritis Workshop page
NIBIB-funded researchers are developing an implantable, biodegradable film that helps to regenerate the native cartilage at the site of damage. Their study, performed in rabbits, could be an initial, important step in the establishment of a new treatment for this common condition, osteoarthritis.