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Scientists Pinpoint Traitorous Immune Cells in Lupus

https://www.niams.nih.gov/scientists-pinpoint-traitorous-immune-cells-lupus

Scientists can distinguish between highly similar cell types using cutting-edge laboratory procedures. Using such techniques, IRP researchers have identified a particular variety of cell in a specific stage of its life cycle as a primary culprit behind the autoimmune disease known as lupus.

Long-running fractures study doubles as a bountiful women’s health data source

https://www.niams.nih.gov/long-running-fractures-study-doubles-bountiful-womens-health-data-source

Systemic Lupus Erythematosus (Lupus)

https://www.niams.nih.gov/health-topics/lupus

What is systemic lupus erythematosus (lupus)? Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body, including the: Skin. Joints. Heart. Lungs. Kidneys. Brain. Lupus happens when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues. This attack causes inflammation and, in some cases, permanent tissue damage. If you have lupus, you may have times of illness (flares) and times of wellness (remission). Lupus flares can be mild to serious, and they do not follow a pattern. However, with treatment, many people with lupus

Osteoporosis

https://www.niams.nih.gov/health-topics/osteoporosis

What is osteoporosis? Osteoporosis is a disease that causes bones to become weak and brittle. This increases your risk of broken bones (fractures). Osteoporosis is a “silent” disease because you may not have symptoms. You may not even know you have the disease until you break a bone. Breaks can occur in any bone but happen most often in: Hip bones. Vertebrae in the spine. Wrist. You can take steps to help prevent osteoporosis and broken bones by: Doing weight-bearing exercises, such as walking or dancing, and lifting weights. Not drinking too much alcohol. Quitting smoking, or not starting if

Roundtable Discussion on Lupus with Congresswoman Lee

https://www.niams.nih.gov/about/meetings-events/visits/roundtable-discussion-lupus-congresswoman-lee

Video of a Facebook Live discussion on lupus research, treatment, and care, moderated by Rev. Cheryl Ward and featuring experts in the field.

Understanding Autoimmune Diseases

https://www.niams.nih.gov/understanding-autoimmune-diseases

Sometimes, your immune system makes mistakes. If it sees your body’s healthy cells as a threat, it may attack them. This can cause an autoimmune disorder.

A Biological Betrayal

https://www.niams.nih.gov/biological-betrayal

Dr. Kaplan has studied a number of autoimmune diseases, from rheumatoid arthritis to vasculitis, but most of her efforts have been focused on what she calls “the poster child” for autoimmune diseases: systemic lupus erythematosus (SLE), more commonly referred to as ‘lupus.’

Casting the NET Wide: How Neutrophils Shape Chronic Autoimmune and Inflammatory Diseases

https://www.niams.nih.gov/casting-net-wide-how-neutrophils-shape-chronic-autoimmune-and-inflammatory-diseases

Known as the “disease with a thousand faces,” systemic lupus erythematosus is a lifelong autoimmune disease with a wide range of symptoms and signs—fatigue, fever, joint pain, facial rash and skin lesions, shortness of breath, and more. It may develop suddenly or slowly and be mild or severe, with people affected going through periods of flare up and remission of their symptoms.

New treatment shows promise in reducing the risk of cardiovascular disease in people with lupus

https://www.niams.nih.gov/newsroom/spotlight-on-research/new-treatment-shows-promise-reducing-risk-cardiovascular-disease

Researchers have identified a potential treatment to reduce the risk of cardiovascular disease in people with systemic lupus erythematosus (SLE), a chronic autoimmune disease.

Living With Scoliosis

https://www.niams.nih.gov/living-scoliosis

An NIH Health Capsule article. Scoliosis is a disease that causes the spine to curve. It can result in an abnormal s-shaped or c-shaped curve. Anyone can get scoliosis. But it’s most common in children age 11 and older.

Exercise Energizes Patients With Autoimmune Disease

https://www.niams.nih.gov/exercise-energizes-patients-autoimmune-disease

Recently, a small IRP study showed that exercise training can help reduce the debilitating fatigue that often accompanies the autoimmune disease known as lupus, and also illuminated some of the underlying mechanisms that may lead to those benefits.

Reactive Arthritis

https://www.niams.nih.gov/health-topics/reactive-arthritis

What is reactive arthritis? Reactive arthritis happens when an infection causes joint pain and swelling. A bacterial infection in the digestive or urinary tract or the genitals usually triggers the condition, but arthritis symptoms typically do not start until a few weeks after you have recovered from the infection. The most common features of reactive arthritis are inflammation of the joints (especially the knees and ankles), eyes, and urinary tract, but not everyone gets all three, or they might not happen at the same time.

Sjögren’s Syndrome

https://www.niams.nih.gov/health-topics/sjogrens-syndrome

What is Sjögren’s syndrome? Sjögren’s syndrome is a chronic (long-lasting) disorder that happens when the immune system attacks the glands that make moisture in the eyes, mouth, and other parts of the body. The main symptoms are dry eyes and mouth, but the disorder may affect other parts of the body. Many people with Sjogren’s syndrome say they feel tired often (fatigue). They also may have joint and muscle pain. In addition, the disease can damage the lungs, kidneys, and nervous system.

Osteonecrosis

https://www.niams.nih.gov/health-topics/osteonecrosis

What is osteonecrosis? Your bones are made up of living cells that need a blood supply to stay healthy. In osteonecrosis, blood flow to part of a bone is reduced. This causes death of bone tissue, and the bone can eventually break down and the joint will collapse. Osteonecrosis can happen to any bone, but most often it develops in the ends of long bones, such as the: Thigh bone. Upper arm bone. Less often, the bones of the elbows, ankles, feet, wrists, and hands are affected. When the disease involves part of a bone in a joint, it can