Systemic Autoimmunity Branch
https://www.niams.nih.gov/labs/kaplan-lab
Led by Dr. Mariana Kaplan, the branch studies autoimmune diseases, like lupus and rheumatoid arthritis, seeking treatments and improved outcomes.
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Laura B. Lewandowski, M.S., M.D.
https://www.niams.nih.gov/about/directory/laura-b-lewandowski-ms-md
Dr. Lewandowski leads a team of scientists studying the genetics of early-onset systemic lupus erythematosus patients in populations around the globe. Her research focuses on genetic drivers of severe disease and inflammation in diverse cohorts worldwide.
Sarthak Gupta, M.D.
https://www.niams.nih.gov/about/directory/sarthak-gupta-md
Sarthak Gupta, M.D., conducts research to better understand sex differences in neutrophil biology. He is also an investigator on several ongoing clinical trials in systemic lupus erythematosus at the NIH.
Mariana J. Kaplan, M.D.
https://www.niams.nih.gov/about/directory/mariana-j-kaplan-md
Dr. Kaplan’s research focuses on identifying the molecular mechanisms that promote the initiation and perpetuation of perturbed immune responses and the development of organ damage and premature vascular disease in systemic autoimmunity.
NIAMS Involvement in the Accelerating Medicines Partnership® (AMP®)
https://www.niams.nih.gov/grants-funding/funded-research/accelerating-medicines
This public-private partnership seeks to develop new ways of identifying and validating promising biological targets for diagnostics and drug development.
Reactive Arthritis
https://www.niams.nih.gov/health-topics/reactive-arthritis
What is reactive arthritis? Reactive arthritis happens when an infection causes joint pain and swelling. A bacterial infection in the digestive or urinary tract or the genitals usually triggers the condition, but arthritis symptoms typically do not start until a few weeks after you have recovered from the infection. The most common features of reactive arthritis are inflammation of the joints (especially the knees and ankles), eyes, and urinary tract, but not everyone gets all three, or they might not happen at the same time.
Osteoarthritis
https://www.niams.nih.gov/health-topics/osteoarthritis
What is osteoarthritis? Osteoarthritis is a joint disease that happens when the tissues in the joint break down over time. It is the most common type of arthritis and is more common in older people. People with osteoarthritis usually have joint pain and, after rest, stiffness (inability to move easily) for a short period of time. The most commonly affected joints include the: Hands (ends of the fingers and at the base and ends of the thumbs). Knees. Hips. Neck. Lower back. Osteoarthritis affects each person differently. For some people, osteoarthritis does not affect day-to-day activities. For others, it causes
Systemic Lupus Erythematosus (Lupus)
https://www.niams.nih.gov/health-topics/lupus
What is systemic lupus erythematosus (lupus)? Systemic lupus erythematosus (lupus) is a chronic (long-lasting) autoimmune disease that can affect many parts of the body, including the: Skin. Joints. Heart. Lungs. Kidneys. Brain. Lupus happens when the immune system, which normally helps protect the body from infection and disease, attacks its own tissues. This attack causes inflammation and, in some cases, permanent tissue damage. If you have lupus, you may have times of illness (flares) and times of wellness (remission). Lupus flares can be mild to serious, and they do not follow a pattern. However, with treatment, many people with lupus
Gout
https://www.niams.nih.gov/health-topics/gout
What is gout? Gout is a type of arthritis that causes pain and swelling in your joints, usually as flares that last for a week or two, and then go away. Gout flares often begin in your big toe or a lower limb. Gout happens when high levels of a substance called serum urate build up in your body. When this happens, needle-shaped crystals form in and around the joint. This leads to inflammation and arthritis of the joint. However, many people with high levels of serum urate will not develop gout. With early diagnosis, treatment, and lifestyle changes, gout
Scientists Pinpoint Traitorous Immune Cells in Lupus
https://www.niams.nih.gov/scientists-pinpoint-traitorous-immune-cells-lupus
Scientists can distinguish between highly similar cell types using cutting-edge laboratory procedures. Using such techniques, IRP researchers have identified a particular variety of cell in a specific stage of its life cycle as a primary culprit behind the autoimmune disease known as lupus.
New clues on tissue damage identified in rheumatoid arthritis and lupus
Research supported by the Accelerating Medicines Partnership (AMP) on Rheumatoid Arthritis and Systemic Lupus Erythematosus (RA/SLE) provides new insights into tissue damage for these autoimmune conditions. Findings include the identification of novel molecular signatures related to immune system signaling in kidney cells that may reflect their active role in disease process; molecular targets, including specific white blood cells, for potential treatment in lupus nephritis; and specific types of fibroblasts and white blood cells that are involved in rheumatoid arthritis.
Engineered cartilage produces anti-inflammatory drug
https://www.niams.nih.gov/engineered-cartilage-produces-anti-inflammatory-drug
Machine learning detects early signs of osteoarthritis
https://www.niams.nih.gov/machine-learning-detects-early-signs-osteoarthritis
Casting the NET Wide: How Neutrophils Shape Chronic Autoimmune and Inflammatory Diseases
Known as the “disease with a thousand faces,” systemic lupus erythematosus is a lifelong autoimmune disease with a wide range of symptoms and signs—fatigue, fever, joint pain, facial rash and skin lesions, shortness of breath, and more. It may develop suddenly or slowly and be mild or severe, with people affected going through periods of flare up and remission of their symptoms.
New treatment shows promise in reducing the risk of cardiovascular disease in people with lupus
Researchers have identified a potential treatment to reduce the risk of cardiovascular disease in people with systemic lupus erythematosus (SLE), a chronic autoimmune disease.
Health Disparities in Osteoarthritis Workshop - July 2022
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Aging (NIA), and National Institute on Minority Health and Health Disparities (NIMHD) are sponsoring a virtual workshop on Health Disparities in Osteoarthritis on Tuesday, July 12 – Wednesday, July 13, 2022, starting at 11:00 AM (ET) each day. The workshop will focus on combining behavioral and biomedical science to address personal, interpersonal, and societal influences that contribute to health disparities in osteoarthritis. Discussions will cover how understanding these disparities can lead to better health in osteoarthritis. Please visit the NIH Health Disparities in Osteoarthritis Workshop page
Roundtable Discussion on Lupus with Congresswoman Lee
https://www.niams.nih.gov/about/meetings-events/visits/roundtable-discussion-lupus-congresswoman-lee
Video of a Facebook Live discussion on lupus research, treatment, and care, moderated by Rev. Cheryl Ward and featuring experts in the field.
Recharging cartilage after knee damage
https://www.niams.nih.gov/recharging-cartilage-after-knee-damage
NIBIB-funded researchers are developing an implantable, biodegradable film that helps to regenerate the native cartilage at the site of damage. Their study, performed in rabbits, could be an initial, important step in the establishment of a new treatment for this common condition, osteoarthritis.
Understanding Autoimmune Diseases
https://www.niams.nih.gov/understanding-autoimmune-diseases
Sometimes, your immune system makes mistakes. If it sees your body’s healthy cells as a threat, it may attack them. This can cause an autoimmune disorder.