Translational Genetics and Genomics Unit
https://www.niams.nih.gov/labs/ombrello-lab
Led by Dr. Michael Ombrello, the unit uses genomic approaches to understand the underlying factors of autoinflammatory and rheumatic diseases.
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Displaying 1 - 15 of 15 results
Alopecia Areata
https://www.niams.nih.gov/health-topics/alopecia-areata
What is alopecia areata? Alopecia areata is a disease that causes hair loss. In alopecia areata, the immune system attacks the structures in skin that form hair (hair follicles). Alopecia areata usually affects the head and face, though hair can be lost from any part of the body. Hair typically falls out in small, round patches about the size of a quarter. In some cases, hair loss is more extensive.
Osteogenesis Imperfecta
https://www.niams.nih.gov/health-topics/osteogenesis-imperfecta
What is osteogenesis imperfecta? Osteogenesis imperfecta (OI) is a disease that causes your bones to break (fracture) easily. OI is also called brittle bone disease. Your symptoms may be mild or severe, depending on the type of OI you have.
Back Pain
https://www.niams.nih.gov/health-topics/back-pain
What is back pain? Back pain is one of the most common medical problems in the United States. It might feel like a dull, constant ache or a sudden, sharp pain. Back pain can result from: An accident. A fall. Lifting something heavy. Changes that happen in the spine as you age. A disorder or medical condition. Treatment depends on the cause and symptoms of your pain. You can do things to improve your health and lower your chance of developing chronic (long-lasting) back pain.
Pemphigus
https://www.niams.nih.gov/health-topics/pemphigus
What is pemphigus? Pemphigus is a rare disease that causes blistering on many parts of the body, including the skin and the inside of the mouth, nose, throat, eyes, and genitals. In pemphigus, the immune system mistakenly attacks cells in the top layer of the skin.
Pachyonychia Congenita
https://www.niams.nih.gov/health-topics/pachyonychia-congenita
What is pachyonychia congenita? Pachyonychia congenita (PC) is a very rare genetic disorder that affects the skin and nails. Most people have thickened nails and calluses on the bottom of the feet. Painful calluses on the soles can make walking difficult. Because of the pain, some people rely on a cane, crutches, or a wheelchair to help with walking.
Autoinflammatory Diseases
https://www.niams.nih.gov/health-topics/autoinflammatory-diseases
What are autoinflammatory diseases? Autoinflammatory diseases refer to problems with the immune system, which usually fights off viruses, bacteria, and infection. The problem causes your immune cells to attack your body by mistake. This can cause swelling that produces fever, rash, joint swelling, or serious buildup of a blood protein in your organs.
Researchers find cause of new autoinflammatory disease
https://www.niams.nih.gov/researchers-find-cause-new-autoinflammatory-disease
Piecing Together the Puzzle of Chronic Low Back Pain
https://www.niams.nih.gov/piecing-together-puzzle-chronic-low-back-pain
The human back is a complex structure with bones, nerves, tendons, discs, and more — all places where something can go wrong and cause pain, which, for many people, becomes a long-term or chronic problem. Life stresses and other medical and mental health conditions aggravate the problem. With so many pieces, it’s hard to get a holistic view of the puzzle or pinpoint the cause of the pain. “People tend to focus on one aspect or another,” said Jeffrey Lotz, Ph.D., a medical engineer who studies back pain at the University of California, San Francisco. “Some people think it’s largely
Close to home: NIH researcher and alopecia patient seeks a cure
https://www.niams.nih.gov/close-home-nih-researcher-and-alopecia-patient-seeks-cure
Engineered cartilage produces anti-inflammatory drug
https://www.niams.nih.gov/engineered-cartilage-produces-anti-inflammatory-drug
How to Manage Low Back Pain Before it Gets Worse
https://www.niams.nih.gov/how-manage-low-back-pain-it-gets-worse
Machine learning detects early signs of osteoarthritis
https://www.niams.nih.gov/machine-learning-detects-early-signs-osteoarthritis
Drugs treat spinal disc degeneration in mice
https://www.niams.nih.gov/drugs-treat-spinal-disc-degeneration-mice
A research team led by Dr. Makarand Risbud of Thomas Jefferson University tested whether treatment with the drugs dasatinib and quercetin would prevent disc degeneration in mice. Both drugs are senolytics, which selectively remove aged cells known as senescent cells.