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In the immune system, T helper cells stimulate B cells to produce antibodies that fight potential disease-causing infections. In people with rheumatoid arthritis (RA), however, B cells produce autoantibodies that attack the body’s own healthy tissues. Researchers have identified a specific type of T helper cells, called T peripheral helper (Tph) cells (stained blue). These cells stimulate B cells (green) to produce autoantibodies in the joints of people with RA. Understanding this mechanism may help scientists develop new treatment targets for the disease.

Michael B. Brenner, M.D., and Deepak Rao, M.D., Ph.D., Brigham and Women’s Hospital, Boston.
Media Type
Scientific Image
Broad Area of Study
Immune System