Autoimmunity Branch

Overview

Principal Investigator

John O’Shea, M.D.

Molecular Immunology and Inflammation Branch

Dr. O’Shea has served on the editorial boards of multiple journals, including: Immunity, Journal of Experimental Medicine, Journal of Biological Chemistry, Journal of Immunology, and Blood. He has been an invited lecturer at numerous universities.

View Complete Profile

Acting Chief

John O’Shea, M.D.

Molecular Immunology and Inflammation Branch

View Complete Profile

Autoimmunity is a central feature of many rheumatic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. The Autoimmunity Branch was established to address the cellular and molecular basis of autoimmunity. A number of work groups have been established within the Autoimmunity Branch to investigate specific aspects of immune cell function as they may pertain to the etiology of autoimmunity.

Staff

Aleksandra Ivovic

Predoctoral Fellow, Autoimmunity Branch

301-435-5986

ivovica@mail.nih.gov

Scientific Publications

Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy.

Klebanoff CA, Scott CD, Leonardi AJ, Yamamoto TN, Cruz AC, Ouyang C, Ramaswamy M, Roychoudhuri R, Ji Y, Eil RL, Sukumar M, Crompton JG, Palmer DC, Borman ZA, Clever D, Thomas SK, Patel S, Yu Z, Muranski P, Liu H, Wang E, Marincola FM, Gros A, Gattinoni L, Rosenberg SA, Siegel RM, Restifo NP

The Journal of clinical investigation.

2016 Jan;

126(1).

doi: 10.1172/JCI81217

PMID: 26657860

The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator.

Richard AC, Ferdinand JR, Meylan F, Hayes ET, Gabay O, Siegel RM

Journal of leukocyte biology.

2015 Sep;

98(3).

doi: 10.1189/jlb.3RI0315-095R

PMID: 26188076

Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9-Producing T Cells.

Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F

Journal of immunology (Baltimore, Md. : 1950).

2015 Dec 15;

195(12).

doi: 10.4049/jimmunol.1502026

PMID: 26637663