Overview

Principal Investigator

Richard Siegel, M.D., Ph.D.

Dr. Siegel's current research interests include regulation of cellular survival and death in the immune system by TNF receptor and other signaling pathways, and the relevance of these pathways to autoimmune diseases and immune tolerance.

Autoimmunity is a central feature of many rheumatic diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. The Autoimmunity Branch was established to address the cellular and molecular basis of autoimmunity. A number of work groups have been established within the Autoimmunity Branch to investigate specific aspects of immune cell function as they may pertain to the etiology of autoimmunity.

Staff

Special Volunteer
Chief
301-496-3761
Biologist
301-496-9896
Post Baccalaureate (IRTA/CRTA)
301 451 7422
Special Volunteer
301-496-5767
Post Baccalaureate (IRTA/CRTA)
301-451-2133
Head
Senior Clinical Fellow Henry Metzger Scholar
301-402-6776
Postdoc Fellow (IRTA)
301-496-5767
Post Baccalaureate IRTA
301-496-5767
Post Baccalaureate IRTA
301-451-3738
Fellow
301-402-6776
Staff Scientist
301-496-9942
Volunteer
301-496-9937
Volunteer
301-496-1565
Special Volunteer
301-451-4362
Volunteer
301-496-9937
Special Volunteer
301-496-5767
Special Volunteer
301-435-1092
Clinical Research Coordinator
301-594-2120
Postdoctoral Fellow
301-496-5767

Scientific Publications

Klebanoff CA, Scott CD, Leonardi AJ, Yamamoto TN, Cruz AC, Ouyang C, Ramaswamy M, Roychoudhuri R, Ji Y, Eil RL, Sukumar M, Crompton JG, Palmer DC, Borman ZA, Clever D, Thomas SK, Patel S, Yu Z, Muranski P, Liu H, Wang E, Marincola FM, Gros A, Gattinoni L, Rosenberg SA, Siegel RM, Restifo NP. Memory T cell-driven differentiation of naive cells impairs adoptive immunotherapy. J Clin Invest. 2016 Jan;126(1):318-34. doi: 10.1172/JCI81217. Epub 2015 Dec 14.

Richard AC, Ferdinand JR, Meylan F, Hayes ET, Gabay O, Siegel RM. The TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspirator. J Leukoc Biol. 2015 Sep;98(3):333-45. doi: 10.1189/jlb.3RI0315-095R. Epub 2015 Jul 17.

Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH4, Gery I, Siegel RM, Meylan F. The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells. J Immunol. 2015 Apr 15;194(8):3567-82. doi: 10.4049/jimmunol.1401220. Epub 2015 Mar 18.

Latest News

Spotlight on Research | March 16, 2015

Autoimmune Disease Super-Regulators Uncovered

Contact Us

Iris Pratt

Secretary
9000 Rockville Pike
Building: 10, Room: 13C103
Bethesda MD 20892
Last Reviewed: 02/14/2017