T cells play an essential role in our immune system. T helper specification is a dynamic, highly regulated process that leads to the clearance of a wide range of antigens.

The Transcriptional Regulation of Lymphocytes Unit focuses on the mechanisms behind T Cell specification. We integrate several next-generation sequencing techniques, such as RNAseq, to look at differential gene expression and ATACseq, to investigate T cell specification at both the transcriptional and epigenetic levels. Using single-cell RNA sequencing, we have identified previously unrecognized factors that play a role in T helper specification.

We are currently characterizing a poorly defined nuclear factor's role in T cell development and T helper specification.

Core Research Facilities

Labs at the NIAMS are supported by the following state-of-the-art facilities and services:

Scientific Publications

Selected Recent Publications

Evolving Views of Long Noncoding RNAs and Epigenomic Control of Lymphocyte State and Memory.

Morrison TA, Hudson WH, Chisolm DA, Kanno Y, Shih HY, Ahmed R, Henao-Mejia J, Hafner M, O'Shea JJ
Cold Spring Harb Perspect Biol.
2022 Jan 4;
doi: 10.1101/cshperspect.a037952
PMID: 34001528

Translating JAKs to Jakinibs.

Gadina M, Chisolm DA, Philips RL, McInness IB, Changelian PS, O'Shea JJ
J Immunol.
2020 Apr 15;
doi: 10.4049/jimmunol.1901477
PMID: 32253269