Autoimmune and other inflammatory diseases result from dysfunctions in the regulation of the immune system. The focus of the Laboratory of Molecular Immunogenetics (LMI) is towards understanding the genetic and molecular regulation involved in normal and abnormal immune cell processes and how these events control immune system regulation and disease. The LMI studies the role of key immune genes in controlling immunoglobulin class switching, DNA repair, immune cell activation, recruitment and function, and regulation of gene expression. Understanding the molecular underpinning on how inflammation is regulated in both health and disease is essential for developing targeted therapeutic agents that can ameliorate immune system disorders with minimal side effects.
The LMI uses a multidisciplinary investigative approach that includes biochemistry, cell biology, immunology, molecular biology, and genetics to explore this problem. The Laboratory also employs cutting edge technologies to facilitate discoveries. The coupling of a multidisciplinary approach with innovative technologies provides a fertile ground for scientific discovery and training.
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