Overview

Autoimmune and other inflammatory diseases result from dysfunctions in the regulation of the immune system. The focus of the Laboratory of Molecular Immunogenetics (LMI) is towards understanding the genetic and molecular regulation involved in normal and abnormal immune cell processes and how these events control immune system regulation and disease. The LMI studies the role of key immune genes in controlling immunoglobulin class switching, DNA repair, immune cell activation, recruitment and function, and regulation of gene expression. Understanding the molecular underpinning on how inflammation is regulated in both health and disease is essential for developing targeted therapeutic agents that can ameliorate immune system disorders with minimal side effects.

The LMI uses a multidisciplinary investigative approach that includes biochemistry, cell biology, immunology, molecular biology, and genetics to explore this problem. The Laboratory also employs cutting edge technologies to facilitate discoveries. The coupling of a multidisciplinary approach with innovative technologies provides a fertile ground for scientific discovery and training.

Staff

Chief
301-402-7858
Postdoctoral Fellow
301-451-6060
Research Fellow
301 435 1514
Visiting Fellow
301-451-7422
Research Fellow
301-402-2128
Postdoctoral Fellow
301-435-5512
Post-doctoral Fellow
301-451-6060
Pre-doctoral IRTA
301-451-7422
Postdoctoral Fellow
301-594-6675
Postdoctoral Fellow
301-480-5852

Image & Media Gallery

Scientific Publications

Kieffer-Kwon KR, Tang Z, Mathe E, Qian J, Sung MH, Li G, Resch W, Baek S, Pruett N, Grøntved L, Vian L, Nelson S, Zare H, Hakim O, Reyon D, Yamane A, Nakahashi H, Kovalchuk AL, Zou J, Joung JK, Sartorelli V, Wei CL, Ruan X, Hager GL, Ruan Y, Casellas R. Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell. 2013 Dec 19;155(7):1507-20. doi: 10.1016/j.cell.2013.11.039.

Kouzine F, Wojtowicz D, Yamane A, Resch W, Kieffer-Kwon KR, Bandle R, Nelson S, Nakahashi H, Awasthi P, Feigenbaum L, Menoni H, Hoeijmakers J, Vermeulen W, Ge H, Przytycka TM, Levens D, Casellas R. Global regulation of promoter melting in naive lymphocytes. Cell. 2013 May 23;153(5):988-99. doi: 10.1016/j.cell.2013.04.033.

Nakahashi H, Kwon KR, Resch W, Vian L, Dose M, Stavreva D, Hakim O, Pruett N, Nelson S, Yamane A, Qian J, Dubois W, Welsh S, Phair RD, Pugh BF, Lobanenkov V, Hager GL, Casellas R. A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code. Cell Rep. 2013 May 22. pii: S2211-1247(13)00206-4. doi: 10.1016/j.celrep.2013.04.024. [Epub ahead of print]

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Last Reviewed: 02/17/2017