The Accelerating Medicines Partnership® Autoimmune and Immune-Mediated Diseases (AMP® AIM) launched in 2021 to deepen our understanding of the cellular and molecular interactions that lead to inflammation and autoimmune diseases. In autoimmune diseases, the body’s immune response is excessive and long-lasting, often causing persistent damage to multiple tissues and organ systems. AMP AIM investigators focus their research on rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), psoriasis, psoriatic arthritis, and Sjögren’s disease. The knowledge gained through these studies will advance the development of new and enhanced treatments for autoimmune diseases. In addition, AMP AIM will drive the development of new research tools, data storage platforms, and data sharing technologies.

AMP AIM builds on and broadens an earlier investment known as the AMP RA/SLE (or RA/Lupus) program. Both AMP AIM and AMP RA/SLE are components of the Accelerating Medicines Partnership (AMP) that was created in 2014 as a collaborative effort between NIH, the U.S. Food and Drug Administration, pharmaceutical companies, and nonprofit organizations. AMP AIM is managed through the Foundation for the NIH, with support from NIAMS, the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Allergy and Infectious Diseases (NIAID), the Office of Research on Women’s Health (ORWH), and thirteen public and private partners.


Although autoimmune diseases are highly complex and variable, they share common inflammatory pathways. AMP AIM investigators seek to identify and define these shared pathways—as well as the cellular and molecular factors that are unique to specific diseases.

The earlier AMP RA/SLE program focused on understanding specific cells and molecules that play a role in rheumatoid arthritis and lupus. AMP AIM extends this single-cell, disease deconstruction approach to additional autoimmune diseases. AMP AIM will also leverage novel, high-dimensional, research tools to uncover cellular interactions that cause inflammation, injury, abnormal function, and clinical disease (disease reconstruction). In particular, the program will examine interactions involving cells in disease-relevant tissues and cells in the innate and adaptive immune systems.

Funding Opportunities [now expired] and Funded Projects

Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases: Disease Teams for Rheumatoid Arthritis, Lupus, Psoriatic Spectrum Diseases and Sjögren’s Syndrome (UC2 Clinical Trial Optional) RFA-AR-21-015

PI(s): Jennifer H. Anolik, M.D., Ph.D., University of Rochester; Laura T. Donlin, Ph.D., Hospital for Special Surgery; and Larry W. Moreland, M.D., University of Colorado Anschutz Medical Campus

Lupus Omics Cutaneous Kidney Investigative Team (LOCKIT)
PI(s): Jill P. Buyon, M.D., New York University School of Medicine; Michelle A. Petri, M.D., M.P.H., Johns Hopkins University; Brad H. Rovin, M.D., Ohio State University; and Victoria P. Werth, M.D., University of Pennsylvania

ELLIPSS: ELucidating the Landscape of Immunoendotypes in Psoriatic Skin and Synovium
PI(s): Christopher T. Ritchlin, M.D., M.P.H., University of Rochester; Johann E. Gudjonsson, M.D., Ph.D., University of Michigan, Ann Arbor; Wilson Liao, M.D., University of California, San Francisco; and Jose U. Scher, M.D., New York University School of Medicine

Sjögren’s Team for Accelerating Medicines Partnership (STAMP)
PI(s): Caroline H. Shiboski, D.D.S, M.P.H., Ph.D., University of California, San Francisco; Alan N. Baer, M.D., Johns Hopkins University; A. Darise Farris, Ph.D., Oklahoma Medical Research Foundation; and Blake M. Warner, D.D.S., Ph.D., M.P.H., National Institute of Dental and Craniofacial Research

Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases: Technology and Analytic Cores (TACs) and Research Management Unit (RMU) (UC2) (Clinical Trials Not Allowed) RFA-AR-21-016

Single Cell and Spatial Genomic Analyses of Specimens From Patients With Autoimmune Diseases (Technology Core)
PI(s): Michael B. Brenner, M.D., Brigham and Women’s Hospital; and Nir Hacohen, Ph.D., Broad Institute, Inc.

Immunogenomics and Systems Biology Core
PI(s): Johann E. Gudjonsson, M.D., Ph.D., Lam Cheung Tsoi, Ph.D., Joshua Welch, Ph.D., and Xiang Zhou, Ph.D., University of Michigan, Ann Arbor

Accelerating Medicines Partnership-Autoimmune and Immunologic Disease Tissue Research Core
PI(s): Joel M. Guthridge, Ph.D., and Judith A. James, M.D., Ph.D., Oklahoma Medical Research Foundation

Integrative Analysis of High Dimensional Tissue Molecular Data to Define Key Biological Systems in Autoimmune Diseases (SBC)
PI(s): Soumya Raychaudhuri, M.D., Ph.D., Brigham and Women’s Hospital

Micro-TeACH (Microbiome Technology and Analytic Center Hub)
PI(s): Jose U. Scher, M.D., and Adriana Heguy, Ph.D., New York University School of Medicine; and Jose Clemente, Ph.D., Icahn School of Medicine at Mount Sinai

Related Information


Project Structure

AMP AIM Structure

Accelerating Medicines Partnership and AMP are registered service marks of the U.S. Department of Health and Human Services.

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