The concept in a RISK pre-application (X02) will be peer-reviewed in an unprecedented way. The X02 review will focus on innovation and significance, with each receiving a separate score. No overall impact score will be given. In the X02 review, the applicants will be anonymous, so their experience, training, track-record, institutional affiliation, seniority and other factors will not enter into evaluating their ideas. This is the first attempt at an NIH review utilizing applicant anonymity.
In the R61/R33 stage, the 5 standard NIH criteria will be used to evaluate the application, with a focus on the design and execution of testing the innovative idea. At this stage, the applicant identity is known to the reviewers.