Clinical Trials in the Spotlight Main Page

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) supports a range of clinical trials studying new and existing interventions for prevention and treatment of arthritis, musculoskeletal, and skin diseases.  Investigators supported by the NIAMS need your help finding individuals to participate in clinical trials.  Participating in clinical trials allows you to play an active role as a volunteer in research and contribute to generating new knowledge about the disease/condition, and potentially future treatments.  The information below is designed to help you quickly learn about actively recruiting research studies for which you or someone you know may be eligible. 

Study Description

Traumatic and debilitating anterior cruciate ligament (ACL) injuries occur at a 2- to 10-fold greater rate in female than male athletes, and 50-100% of females develop knee osteoarthritis within 12-20 years of initial injury. The National Public Health Agenda for Osteoarthritis recommends expanding and refining evidence-based prevention of ACL injury to reduce this burden. The study team has identified modifiable risk factors that predict ACL injury in young female athletes. The lab-based neuromuscular training targets modifiable risk factors and shows statistical efficacy in high-risk athletes, but a meaningful risk re-categorization to "low-risk" has not been achieved.  The overall objective of this proposal is to implement and test innovative augmented neuromuscular training (aNMT) methods to enhance sensorimotor learning and more effectively reduce biomechanical risk factors for ACL injury.

aNMT biofeedback integrates biomechanics screening with portable augmented reality glasses to display real-time feedback, which maps complex biomechanical variables onto simple visual stimuli that athletes intuitively "control" via their own movements. The preliminary data on aNMT demonstrate the proficiency in implementing this technology and the efficacy of the approach to efficiently induce desired training adaptations. The study's central hypothesis is that sensorimotor biofeedback will improve localized joint mechanics and reduce global injury risk in evidence-based measures collected in laboratory tasks and in realistic, sport-specific virtual reality scenarios. Once the objectives of this application are achieved, the study team expects to both optimize the efficiency and enhance the efficacy of feedback for personalized and targeted injury prevention and establish the potential for enhanced sensorimotor adaptions from aNMT to translate to the field of play.

ELIGIBILITY CRITERIA:

Ages Eligible for Study: 12 -19 years (Child, Adult)

Sexes Eligible for Study: Female

Accepts Healthy Volunteers: Yes

Inclusion Criteria:

  • Actively participate on the soccer, volleyball, or basketball team.

Exclusion Criteria:

          Do not participate on the soccer, volleyball, or basketball team.

Study Design:

Allocation: Randomized

Intervention Model: Parallel Assignment

Masking: Single (Participant)

Primary Purpose: Prevention

Study Location(s):

Cincinanti Childrens Hospital Medical Center, Cincinnati, Ohio, United States, 45229

Study Website:

https://clinicaltrials.gov/ct2/show/NCT02933008?term=NCT02933008&rank=1

Last Updated: August 2019