William Newcomb has over 30 years of experience in the lab, working primarily with Herpes simplex virus, as well as vesicular stomatitis virus and bovine papilloma virus. His research areas include growth and purification of virus and isolation and characterization of replicative intermediates and sub viral structures. He also works with protein expression and crystallization.

Research Statement

Mr. Newcomb’s primary research interests include isolation, purification and characterization of the primary enveloped virion (PEV), procapsid, portal complex and pUL36 protein of herpes simplex type 1. He is also involved in a project that entails the purification and  characterization of S9 bacteriophage procapsid.

Scientific Publications

Internal Proteins of the Procapsid and Mature Capsids of Herpes Simplex Virus 1 Mapped by Bubblegram Imaging.

Wu W, Newcomb WW, Cheng N, Aksyuk A, Winkler DC, Steven AC
Journal of virology.
2016 May 15;
doi: 10.1128/JVI.03224-15
PMID: 26984725

Subassemblies and asymmetry in assembly of herpes simplex virus procapsid.

Aksyuk AA, Newcomb WW, Cheng N, Winkler DC, Fontana J, Heymann JB, Steven AC
2015 Oct 6;
doi: 10.1128/mBio.01525-15
PMID: 26443463

The UL36 tegument protein of herpes simplex virus 1 has a composite binding site at the capsid vertices.

Cardone G, Newcomb WW, Cheng N, Wingfield PT, Trus BL, Brown JC, Steven AC
Journal of virology.
2012 Apr;
doi: 10.1128/JVI.00012-12
PMID: 22345483

Structure of the herpes simplex virus capsid. Molecular composition of the pentons and the triplexes.

Newcomb WW, Trus BL, Booy FP, Steven AC, Wall JS, Brown JC
Journal of molecular biology.
1993 Jul 20;

Uncoating the herpes simplex virus genome.

Newcomb WW, Booy FP, Brown JC
Journal of molecular biology.
2007 Jul 20;


University of Mississippi School of Medicine

Earlham College


Research Associate
Department of Microbiology, University of Virginia Medical School, 1978–2012

Last Updated: June 2020