Dr. Vivek Thumbigere Math graduated with a Bachelor of Dental Surgery degree in 2003 from Sri Siddhartha Dental College, India. He then received a certificate in periodontology in 2011 and a Ph.D. in oral biology in 2013 from the University of Minnesota School of Dentistry. He came to the NIH in 2013 for postdoctoral training in the Laboratory of Oral and Connective Tissue Biology. Dr. Thumbigere Math is a diplomate of the American Board of Periodontology.

Research Statement

Dr. Vivek Thumbigere Math’s research focuses on studying the molecular biology of dental-oral-craniofacial development, with an emphasis on the periodontal complex. We aim to understand cells and signals influencing tooth, bone, and periodontal ligament development in order to identify improved regenerative strategies. A variety of approaches are taken, including in vitro cell and organ culture, transgenic animal models for studying gene function, in vivo models for studying periodontal repair and regeneration, and studies involving human subjects focusing on genetic disorders and pathologies affecting the dentoalveolar complex. These studies should provide greater insight on all hard and soft connective tissues, as well as help identify links between systemic conditions and the oral cavity.

Our lab's recent focus areas have been:
Role of phosphate and pyrophosphate metabolism in physiology and pathology of the dentoalveolar complex.
Role of extracellular matrix proteins and signaling molecules in development of the tooth root and differentiation of associated cell types.
Novel approaches for periodontal regeneration.

Scientific Publications

A Familial Pattern of Multiple Idiopathic Cervical Root Resorption With a 30-Year Follow-Up.

Neely AL, Thumbigere-Math V, Somerman MJ, Foster BL
Journal of periodontology.
2016 Apr;
doi: 10.1902/jop.2015.150536
PMID: 26561999

PTH and Vitamin D Repress DMP1 in Cementoblasts.

Wang L, Tran AB, Nociti FH Jr, Thumbigere-Math V, Foster BL, Krieger CC, Kantovitz KR, Novince CM, Koh AJ, McCauley LK, Somerman MJ
Journal of dental research.
2015 Oct;
doi: 10.1177/0022034515599726
PMID: 26276370

Serum Markers of Bone Turnover and Angiogenesis in Patients With Bisphosphonate-Related Osteonecrosis of the Jaw After Discontinuation of Long-Term Intravenous Bisphosphonate Therapy.

Thumbigere-Math V, Michalowicz BS, Hughes PJ, Basi DL, Tsai ML, Swenson KK, Rockwell L, Gopalakrishnan R
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2016 Apr;
doi: 10.1016/j.joms.2015.09.028
PMID: 26501428

Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw.

Thumbigere-Math V, Michalowicz BS, de Jong EP, Griffin TJ, Basi DL, Hughes PJ, Tsai ML, Swenson KK, Rockwell L, Gopalakrishnan R
Oral diseases.
2015 Jan;
doi: 10.1111/odi.12204
PMID: 24286378

Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw.

Thumbigere-Math V, Michalowicz BS, Hodges JS, Tsai ML, Swenson KK, Rockwell L, Gopalakrishnan R
Journal of periodontology.
2014 Feb;
doi: 10.1902/jop.2013.130017
PMID: 23786404

A retrospective study evaluating frequency and risk factors of osteonecrosis of the jaw in 576 cancer patients receiving intravenous bisphosphonates.

Thumbigere-Math V, Tu L, Huckabay S, Dudek AZ, Lunos S, Basi DL, Hughes PJ, Leach JW, Swenson KK, Gopalakrishnan R
American journal of clinical oncology.
2012 Aug;
doi: 10.1097/COC.0b013e3182155fcb
PMID: 22561331


University of Minnesota, School of Dentistry
Ph.D., Oral Biology, 2013

Univ. of Minnesota, School of Dentistry
Certificate in Periodontology, 2011

Sri Siddhartha Dental College, Kamataka, India
Bachelor of Dental Surgery (B.D.S.), 2002


Clinical/Research Fellow
Laboratory of Oral and Connective Tissue Biology, NIAMS, Oct 2013–Present

Dean’s Faculty Member
University of Maryland School of Dentistry, Jan 2011–Present

Adjunct Assistant Professor
University of Minnesota, School of Dentistry, Sep 2011–Aug 2013

Dental Fellow Specialist
University of Minnesota, School of Dentistry, May 2008–May 2011

Graduate Research Assistant
University of Minnesota, School of Dentistry, Oct 2004–May 2013

Last Updated: September 2020