Dr. Vance Holt received his doctorate degree in Stem Cell and Developmental Biology from Case Western Reserve University, Cleveland, Ohio where his focus was on mesenchymal stem cell and adipocyte biology in the aging bone marrow. During his graduate work, Dr. Holt identified a novel role for adipocytes in regulating bone metabolism in the absence of normal bone homeostasis. Dr. Holt joined the Colbert Lab in the Pediatric Translational Research Branch in 2015 to study cytokines that may drive aberrant mineralization in axial spondyloarthritis. In 2015 Dr. Holt also joined the inaugural Diversity Task Force Committee at the Center for Cancer Training at NCI, whose mission is to develop novel strategies and promote existing strategies to recruit outstanding scientists from underrepresented backgrounds.
Dr. Holt is studying effects of cytokines including TNF, IFN-g, IL-17, and IL-22 on induced pluripotent stem (iPS) cells, iPS-derived mesenchymal stem cells (MSCs), and MSC-derived osteoblasts, colon organoids, and keratinocytes relevant to the pathogenesis of spondyloarthritis and related diseases.