Summary

Dr. Tejpal Gill is a research fellow in the Pediatric Translational Research Branch (PTRB) where she is studying the complex relationship between gut microbiota and experimental spondyloarthritis (SpA) in HLA-B27 transgenic rats. Previously, she described a novel mechanism for the proinflammatory effects of mitochondrial ROS in modulating T cell receptor (TCR) mediated activation, suggesting that changes in T cell microenvironment determine its response during inflammation.

Research Statement

Expression of HLA-B27, a major risk factor for spondyloarthritis (SpA), in a rat model reproduces key features of human SpA including gut inflammation. Dr. Gill and her coworkers are evaluating how the effects of HLA-B27 on gut microbiota are shaped by genetic background and environment. She is interested in host-pathogen interactions at cellular and metabolic levels, and would like to be able to translate these findings into better therapies to ameliorate disease.

Education

Institute of Himalayan Bioresource Technology, (CSIR), Palampur, H.P. India.
Ph.D., Biotechnology, 2010

Experience

Postdoctoral Fellow
Division of Gastroenterology and Liver Diseases, Case Western Reserve University, 2010 - 2013

Last Reviewed: 03/03/2017