Summary

Dr. Tejpal Gill is a research fellow in the Pediatric Translational Research Branch (PTRB) where she is studying the complex relationship between gut microbiota and experimental spondyloarthritis (SpA) in HLA-B27 transgenic rats. Previously, she described a novel mechanism for the proinflammatory effects of mitochondrial ROS in modulating T cell receptor (TCR) mediated activation, suggesting that changes in T cell microenvironment determine its response during inflammation.

Research Statement

Expression of HLA-B27, a major risk factor for spondyloarthritis (SpA), in a rat model reproduces key features of human SpA including gut inflammation. Dr. Gill and her coworkers are evaluating how the effects of HLA-B27 on gut microbiota are shaped by genetic background and environment. She is interested in host-pathogen interactions at cellular and metabolic levels, and would like to be able to translate these findings into better therapies to ameliorate disease.

Scientific Publications

The intestinal microbiome in spondyloarthritis.

Gill T, Asquith M, Rosenbaum JT, Colbert RA
Current opinion in rheumatology.
2015 Jul;
27(4).
doi: 10.1097/BOR.0000000000000187
PMID: 26002022

HLA-B27 and human β2-microglobulin affect the gut microbiota of transgenic rats.

Lin P, Bach M, Asquith M, Lee AY, Akileswaran L, Stauffer P, Davin S, Pan Y, Cambronne ED, Dorris M, Debelius JW, Lauber CL, Ackermann G, Baeza YV, Gill T, Knight R, Colbert RA, Taurog JD, Van Gelder RN, Rosenbaum JT
PloS one.
2014;
9(8).
doi: 10.1371/journal.pone.0105684
PMID: 25140823

Mitochondria-derived hydrogen peroxide selectively enhances T cell receptor-initiated signal transduction.

Gill T, Levine AD
The Journal of biological chemistry.
2013 Sep 6;
288(36).
doi: 10.1074/jbc.M113.476895
PMID: 23880762

TGF-β conditions intestinal T cells to express increased levels of miR-155, associated with down-regulation of IL-2 and itk mRNA.

Das LM, Torres-Castillo MD, Gill T, Levine AD
Mucosal immunology.
2013 Jan;
6(1).
doi: 10.1038/mi.2012.60
PMID: 22785227

Education

Institute of Himalayan Bioresource Technology, (CSIR), Palampur, H.P. India.
Ph.D., Biotechnology, 2010

Experience

Postdoctoral Fellow
Division of Gastroenterology and Liver Diseases, Case Western Reserve University, 2010 - 2013

Last Updated: June 2020