Smrity Sahu completed her Ph.D. at the Postgraduate Institute of Medical Education and Research (PGIMER) in India. Her thesis explored skeletal manifestations in Signal Transducer and Activator of Transcription factor 3 (STAT3)-associated Hyper IgE Syndrome patients and how osteoclast generation and function regulate these manifestations.

As a research fellow, she engaged in diverse projects. One, funded by the Indian Council of Medical Research (ICMR) and led by Dr. Seema Chhabra in the Department of Immunopathology at PGIMER, focused on antigen-specific immunological evaluation induced by Mycobacterium indicus pranii (MIP) or Bacille Calmette-Guerin (BCG) vaccines as adjunctive immunotherapy in multibacillary leprosy patients under multidrug therapy.

Additionally, Dr. Sahu worked on the "Studies for Diagnosis, Research, and Therapy of Primary Immune Deficiency Diseases (PIDS)" project at the ICMR Department of Health Research. This endeavor was overseen by Professors Surjit Singh and Biman Saikia.