Summary

Dr. Shubham Goel is post-doctoral visiting fellow in the Cutaneous Leukocyte Biology Section at the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

Since 2011, Dr. Goel has conducted research in the molecular mechanism of Primary Immunodeficiency Diseases (PIDs) to understand the clinical and basic aspects of the disease pathophysiology while supporting medical health care.

Research Statement

PIDs patients are affected by microorganism communities either alone or in combination. For example, a CARD9 deficiency mainly affects the fungal infection of one phylum (Ascomycota), while a STAT3 deficiency might lead to a Staph aureus and CMC infection. On the other hand, DOCK8 deficient patients present with viral infections only. Thus, a unique infection profile is evident for each immune gene defect suggesting their distinct role in maintaining skin homeostasis. Using a sample of patients and a mice model, and with the help of high-throughput techniques like single-cell RNA-seq, it will be possible to relate the mechanism of the susceptibility of a single type of infection to one type of gene defect.

In the future, Dr. Goel plans to develop a new diagnostic assay and delineate the molecular mechanism of unknown and new PIDs with respect to skin biology and infections.

Scientific Publications

Expression of CD40 Ligand on T Cells and Soluble CD40 Ligand in Children With Kawasaki Disease: A Single-Center Preliminary Study From North India.

Jindal AK, Rawat A, Goel S, Shandilya J, Saikia B, Minz RW, Singh S
J Clin Rheumatol.
2021 Aug 1;
27(5).
doi: 10.1097/RHU.0000000000001283
PMID: 31985724

Myriad Faces of Chronic Granulomatous Disease: All in an Indian Family with Novel CYBB Defect.

Vignesh P, Sharma M, Pilania RK, Shandilya JK, Kaur A, Goel S, Kaur A, Suri D, Rawat A, Dalal A, Sarma AS, Singh S
J Clin Immunol.
2019 Aug;
39(6).
doi: 10.1007/s10875-019-00661-0
PMID: 31338742

Clinical and molecular features of X-linked hyper IgM syndrome - An experience from North India.

Rawat A, Mathew B, Pandiarajan V, Jindal A, Sharma M, Suri D, Gupta A, Goel S, Karim A, Saikia B, Minz RW, Imai K, Nonoyama S, Ohara O, Giliani SC, Notarangelo LD, Chan KW, Lau YL, Singh S
Clin Immunol.
2018 Oct;
195().
doi: 10.1016/j.clim.2018.07.013
PMID: 30053428

STAT3-Mediated Transcriptional Regulation of Osteopontin in STAT3 Loss-of-Function Related Hyper IgE Syndrome.

Goel S, Sahu S, Minz RW, Singh S, Suri D, Oh YM, Rawat A, Sehgal S, Saikia B
Front Immunol.
2018;
9().
doi: 10.3389/fimmu.2018.01080
PMID: 29868029

Large BTK gene mutation in a child with X-linked agammaglobulinemia and polyarthritis.

Sharma D, Gupta A, Goel S, Sharma M, Rawat A, Singh S
Clin Immunol.
2017 Oct;
183().
doi: 10.1016/j.clim.2017.08.005
PMID: 28807838

Severe Aspergillus Pneumonia and Pulmonary Artery Hypertension in a Child with Autosomal Recessive Chronic Granulomatous Disease and Selective IgA Deficiency.

Jindal AK, Rawat A, Suri D, Sharma M, Shandilya JK, Goel S, Sodhi KS, Singh S
J Clin Immunol.
2017 May;
37(4).
doi: 10.1007/s10875-017-0386-6
PMID: 28342009

Novel Mutation in SH2 Domain of STAT3 (p.M660T) in Hyper-IgE Syndrome with Sterno-Clavicular and Paravertebral Abscesses.

Saikia B, Goel S, Suri D, Minz RW, Rawat A, Singh S
Indian J Pediatr.
2017 Jun;
84(6).
doi: 10.1007/s12098-017-2336-y
PMID: 28315006

TH17 Cells in STAT3 Related Hyper-IgE Syndrome.

Sharma S, Saikia B, Goel S, Rawat A, Minz RW, Suri D, Chhabra S, Singh S
Indian J Pediatr.
2016 Oct;
83(10).
doi: 10.1007/s12098-016-2150-y
PMID: 27226025

Hyper-IgE syndrome with a novel STAT3 mutation-a single center study from India.

Saikia B, Suri D, Goel S, Rawat A, Minz RW, Gupta A, Sharma S, Ohara O, Imai K, Nonoyama S, Sehgal S, Singh S
Asian Pac J Allergy Immunol.
2014 Dec;
32(4).
doi: 10.12932/AP0456.32.4.2014
PMID: 25543043

Spontaneously occurring micronuclei in infiltrating ductal carcinoma of breast: a potential biomarker for aggressive phenotype detection?

Goel S, Bhatia A, Dey P
Diagn Cytopathol.
2013 Apr;
41(4).
doi: 10.1002/dc.21836
PMID: 21987354

Education

Department of Immunopathology, PGIMER, Chandigarh, India
Ph.D. (Immunology)

Department of Experimental Medicine and Biotechnology, PGIMER, Chandigarh, India
M.Sc. (Medical Biotechnology)

Department of Microbiology, Swami Shraddhanand College, University of Delhi, India
BSc (H) Microbiology

Experience

Department of Laboratory Medicine, National Institutes of Health
Post-Doctoral Visiting Fellow (2017-Present)

Department of Pediatrics, Advance Pediatrics Center, PGIMER, Chandigarh, India
Research Associate (2016-2017)

Department of Immunopathology, PGIMER, Chandigarh, India
ICMR-Senior Research Fellow (2015-2016)

Last Updated: September 2020