As a graduate student in Dr. Stefanie Vogel’s lab at the University of Maryland School of Medicine, Dr. Mistry characterized the molecular mechanism of inhibition of a small molecule and its analog and demonstrated their ability to inhibit TLR2 signaling in human and murine cells both in vitro and in vivo. Using site-directed mutagenesis, he identified divergent roles of TLR2 BB loop residues for TLR2/1 and TLR2/6 signaling. Dr. Mistry worked as a faculty research assistant in Dr. Kevin McIver’s lab at the University of Maryland College Park and helped develop genetic tools for mutageneis in S. pyogenes. He helped construct a mariner-based transposon that was used to perform Transposon-Site Hybridization in several invasive serotypes of Group A Streptococcus which helped to identify genes required for fitness.
Dr. Mistry is characterizing various neutrophil subsets including low-density granulocytes in autoimmune and autoinflammatory disorders using ATAC-Seq and RNA-Seq.