Summary

As a graduate student in Dr. Stefanie Vogel’s lab at the University of Maryland School of Medicine, Dr. Mistry characterized the molecular mechanism of inhibition of a small molecule and its analog and demonstrated their ability to inhibit TLR2 signaling in human and murine cells both in vitro and in vivo. Using site-directed mutagenesis, he identified divergent roles of TLR2 BB loop residues for TLR2/1 and TLR2/6 signaling. Dr. Mistry worked as a faculty research assistant in Dr. Kevin McIver’s lab at the University of Maryland College Park and helped develop genetic tools for mutageneis in S. pyogenes. He helped construct a mariner-based transposon that was used to perform Transposon-Site Hybridization in several invasive serotypes of Group A Streptococcus which helped to identify genes required for fitness.

Research Statement

Dr. Mistry is characterizing various neutrophil subsets including low-density granulocytes in autoimmune and autoinflammatory disorders using ATAC-Seq and RNA-Seq.

Education

University of Maryland School of Medicine
Ph.D., Microbiology and Immunology, 2015

University of Maryland College Park
B.S., Biochemistry, 2008

Experience

Postdoctoral Fellow
Systemic Autoimmunity Branch, NIAMS, NIH

Faculty research assistant
University of Maryland, College Park

Last Reviewed: 03/22/2017