Leslie Castelo-Soccio, M.D., Ph.D. received her undergraduate degree from Harvard University and her medical and doctoral degrees from the Tri-Institutional MD-PhD program at Cornell University.  After training in dermatology at the University of Pennsylvania, she completed a pediatric dermatology fellowship at the Children's Hospital of Philadelphia and a post-doctoral fellowship in the laboratory of George Cotsarelis, M.D. at the University of Pennsylvania. From 2011-2021, Dr. Castelo-Soccio was an assistant professor of pediatrics and dermatology at the University of Pennsylvania Perelman School of Medicine and also the research director and an attending physician in pediatric dermatology at the Children's Hospital of Philadelphia. 

She currently serves as co-director of the Hair Disorders Focus Study Group for the Pediatric Dermatology Research Alliance and is an attending physician on the NIH Dermatology Consultation Service.

Research Statement

Dr. Castelo-Soccio's research covers the natural history of pediatric alopecia areata including epidemiology, associated co-morbidities, and response to therapy. She specializes in the use of imaging tools and develops guidelines for pediatric alopecia. Dr. Castelo-Soccio also studies the microbiome of hair disorders with the goal of developing therapies targetting dysbiosis and immune system dysregulation. 

Scientific Publications

Protein kinases: drug targets for immunological disorders.

Castelo-Soccio L, Kim H, Gadina M, Schwartzberg PL, Laurence A, O'Shea JJ
Nat Rev Immunol.
2023 Dec;
doi: 10.1038/s41577-023-00877-7
PMID: 37188939

Alopecia areata flare patterns in children and young adults while on systemic tofacitinib.

McKenzie PL, Castelo-Soccio L
J Am Acad Dermatol.
2022 Mar;
doi: 10.1016/j.jaad.2021.02.071
PMID: 33667538

Dupilumab therapy for alopecia areata in pediatric patients with concomitant atopic dermatitis.

McKenzie PL, Castelo-Soccio L
J Am Acad Dermatol.
2021 Jun;
doi: 10.1016/j.jaad.2021.01.046
PMID: 33484763

Acral Changes in pediatric patients during COVID 19 pandemic: Registry report from the COVID 19 response task force of the society of pediatric dermatology (SPD) and pediatric dermatology research alliance (PeDRA).

Castelo-Soccio L, Lara-Corrales I, Paller AS, Bean E, Rangu S, Oboite M, Flohr C, Ahmad RC, Calberg V, Gilliam A, Pope E, Reynolds S, Sibbald C, Shin HT, Berger E, Schaffer J, Siegel MP, Cordoro KM
Pediatr Dermatol.
2021 Mar;
doi: 10.1111/pde.14566
PMID: 33742457

Photographing Alopecia: How Many Pixels Are Needed for Clinical Evaluation?

Bayramova A, Mane T, Hopkins C, Zheng Y, Ogunleye TA, Taylor SC, Castelo-Soccio L, Bernardis E
J Digit Imaging.
2020 Dec;
doi: 10.1007/s10278-020-00389-z
PMID: 33009638

Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations.

Onoufriadis A, Cabezas A, Ng JCF, Canales J, Costas MJ, Ribeiro JM, Rodrigues JR, McAleer MA, Castelo-Soccio L, Simpson MA, Fraternali F, Irvine AD, Cameselle JC, McGrath JA
Br J Dermatol.
2021 May;
doi: 10.1111/bjd.19481
PMID: 32790068

Understanding alopecia areata characteristics in children under the age of 4 years.

Rangu S, Rogers R, Castelo-Soccio L
Pediatr Dermatol.
2019 Nov;
doi: 10.1111/pde.13990
PMID: 31468560

Severity of disease and quality of life in parents of children with alopecia areata, totalis, and universalis: A prospective, cross-sectional study.

Putterman E, Patel DP, Andrade G, Harfmann KL, Hogeling M, Cheng CE, Goh C, Rogers RS, Castelo-Soccio L
J Am Acad Dermatol.
2019 May;
doi: 10.1016/j.jaad.2018.12.051
PMID: 30633941

Topical 2% tofacitinib for children with alopecia areata, alopecia totalis, and alopecia universalis.

Putterman E, Castelo-Soccio L
J Am Acad Dermatol.
2018 Jun;
doi: 10.1016/j.jaad.2018.02.031
PMID: 29754888

Pediatric severity of alopecia tool.

Bernardis E, Nukpezah J, Li P, Christensen T, Castelo-Soccio L
Pediatr Dermatol.
2018 Jan;
doi: 10.1111/pde.13327
PMID: 29105836


Cornell University
M.D. (2005)

Cornell University
Ph.D. (2004)

Harvard University
B.A. Biological Sciences (1997)


Assistant Professor/Attending Physician
University of Pennsylvania School of Medicine and Children’s Hospital of Philadelphia (2011-2021)

Pediatric Dermatology Fellowship
Children’s Hospital of Philadelphia (2010-2011)

Post-Doctoral Fellowship
University of Pennsylvania (2009-2010)

Dermatology Residency
University of Pennsylvania (2006-2009)

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