Summary

Krishan Kumar Thakur completed his Ph.D. in biosciences and bioengineering in September 2021 from the Indian Institute of Technology Guwahati, India. His Ph.D. work was primarily focused on the expression of lipocalin receptor in triple-negative breast cancer (TNBC). Through his research, Dr. Thakur showcased that lipocalin receptor is significantly upregulated in TNBC and leads to the tumorigenesis of the disease.

Dr. Thakur came to the NIH in November 2021 as a postdoctoral fellow to work with Dr. Pravitt Gourh in the Scleroderma Genomics and Health Disparities Unit of the NIAMS.

Research Statement

Dr. Thakur is interested in understanding the genetic risk factors involved in scleroderma pathogenesis. Moreover, he is studying the expression of transforming growth factor beta (TGF-β) and the role TGF-β plays in scleroderma pathogenesis.

Scientific Publications

Loss of TIPE3 reduced the proliferation, survival and migration of lung cancer cells through inactivation of Akt/mTOR, NF-κB, and STAT-3 signaling cascades.

Bordoloi D, Harsha C, Padmavathi G, Banik K, Sailo BL, Roy NK, Girisa S, Thakur KK, Khwairakpam AD, Chinnathambi A, Alahmadi TA, Alharbi SA, Shakibaei M, Kunnumakkara AB
Life Sci.
2022 Mar 15;
293().
doi: 10.1016/j.lfs.2022.120332
PMID: 35041835

A novel bioavailable curcumin-galactomannan complex modulates the genes responsible for the development of chronic diseases in mice: A RNA sequence analysis.

Banik K, Khatoon E, Hegde M, Thakur KK, Puppala ER, Naidu VGM, Kunnumakkara AB
Life Sci.
2021 Dec 15;
287().
doi: 10.1016/j.lfs.2021.120074
PMID: 34687757

Long noncoding RNAs in triple-negative breast cancer: A new frontier in the regulation of tumorigenesis.

Thakur KK, Kumar A, Banik K, Verma E, Khatoon E, Harsha C, Sethi G, Gupta SC, Kunnumakkara AB
J Cell Physiol.
2021 Dec;
236(12).
doi: 10.1002/jcp.30463
PMID: 34105151

COVID-19, cytokines, inflammation, and spices: How are they related?

Kunnumakkara AB, Rana V, Parama D, Banik K, Girisa S, Henamayee S, Thakur KK, Dutta U, Garodia P, Gupta SC, Aggarwal BB
Life Sci.
2021 Nov 1;
284().
doi: 10.1016/j.lfs.2021.119201
PMID: 33607159

Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis.

Bordoloi D, Banik K, Vikkurthi R, Thakur KK, Padmavathi G, Sailo BL, Girisa S, Chinnathambi A, Alahmadi TA, Alharbi SA, Buhrmann C, Shakibaei M, Kunnumakkara AB
Life Sci.
2020 Dec 1;
262().
doi: 10.1016/j.lfs.2020.118475
PMID: 32976884

Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases.

Parama D, Boruah M, Yachna K, Rana V, Banik K, Harsha C, Thakur KK, Dutta U, Arya A, Mao X, Ahn KS, Kunnumakkara AB
Life Sci.
2020 Nov 1;
260().
doi: 10.1016/j.lfs.2020.118182
PMID: 32781063

Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives.

Khatoon E, Banik K, Harsha C, Sailo BL, Thakur KK, Khwairakpam AD, Vikkurthi R, Devi TB, Gupta SC, Kunnumakkara AB
Semin Cancer Biol.
2022 May;
80().
doi: 10.1016/j.semcancer.2020.06.014
PMID: 32610149

Inflammation, NF-κB, and Chronic Diseases: How are They Linked?

Kunnumakkara AB, Shabnam B, Girisa S, Harsha C, Banik K, Devi TB, Choudhury R, Sahu H, Parama D, Sailo BL, Thakur KK, Gupta SC, Aggarwal BB
Crit Rev Immunol.
2020;
40(1).
doi: 10.1615/CritRevImmunol.2020033210
PMID: 32421977

An Update on Pharmacological Potential of Boswellic Acids against Chronic Diseases.

Roy NK, Parama D, Banik K, Bordoloi D, Devi AK, Thakur KK, Padmavathi G, Shakibaei M, Fan L, Sethi G, Kunnumakkara AB
Int J Mol Sci.
2019 Aug 22;
20(17).
doi: 10.3390/ijms20174101
PMID: 31443458

Cancer drug development: The missing links.

Kunnumakkara AB, Bordoloi D, Sailo BL, Roy NK, Thakur KK, Banik K, Shakibaei M, Gupta SC, Aggarwal BB
Exp Biol Med (Maywood).
2019 May;
244(8).
doi: 10.1177/1535370219839163
PMID: 30961357

Upside and Downside of Tumor Necrosis Factor Blockers for Treatment of Immune/Inflammatory Diseases.

Kunnumakkara AB, Thakur KK, Rana V, Bora B, Banik K, Khatoon E, Sailo BL, Shabnam B, Girisa S, Gupta SC, Aggarwal BB
Crit Rev Immunol.
2019;
39(6).
doi: 10.1615/CritRevImmunol.2020033205
PMID: 32421957

Possible use of Punica granatum (Pomegranate) in cancer therapy.

Khwairakpam AD, Bordoloi D, Thakur KK, Monisha J, Arfuso F, Sethi G, Mishra S, Kumar AP, Kunnumakkara AB
Pharmacol Res.
2018 Jul;
133().
doi: 10.1016/j.phrs.2018.04.021
PMID: 29729421

Alarming Burden of Triple-Negative Breast Cancer in India.

Thakur KK, Bordoloi D, Kunnumakkara AB
Clin Breast Cancer.
2018 Jun;
18(3).
doi: 10.1016/j.clbc.2017.07.013
PMID: 28801156

Therapeutic implications of toll-like receptors in peripheral neuropathic pain.

Thakur KK, Saini J, Mahajan K, Singh D, Jayswal DP, Mishra S, Bishayee A, Sethi G, Kunnumakkara AB
Pharmacol Res.
2017 Jan;
115().
doi: 10.1016/j.phrs.2016.11.019
PMID: 27894923

The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease.

Gadhave K, Bolshette N, Ahire A, Pardeshi R, Thakur K, Trandafir C, Istrate A, Ahmed S, Lahkar M, Muresanu DF, Balea M
J Cell Mol Med.
2016 Jul;
20(7).
doi: 10.1111/jcmm.12817
PMID: 27028664

Role of toll-like receptors in multiple myeloma and recent advances.

Thakur KK, Bolshette NB, Trandafir C, Jamdade VS, Istrate A, Gogoi R, Cucuianu A
Exp Hematol.
2015 Mar;
43(3).
doi: 10.1016/j.exphem.2014.11.003
PMID: 25462020

Protein folding and misfolding in the neurodegenerative disorders: a review.

Bolshette NB, Thakur KK, Bidkar AP, Trandafir C, Kumar P, Gogoi R
Rev Neurol (Paris).
2014 Mar;
170(3).
doi: 10.1016/j.neurol.2013.11.002
PMID: 24613386

Education

Indian Institute of Technology, Guwahati, India
Ph.D., Biosciences and Bioengineering (2021)

National Institute of Pharmaceutical Education and Research, Guwahati, India
M.S., (Pharmacy) Biotechnology (2014)

RGPV, Bhopal, India
B.S., Pharmacy (2012)

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