Summary

Dr. Sikora is a board certified pediatric rheumatologist who joined the National Institutes of Health as a Henry Metzger Scholar in Translational Research after successfully completing his fellowship in pediatric rheumatology. He currently devotes his time in studying the pathogenesis of pediatric inflammatory disease, including juvenile arthritis and relapsing polychondritis.

Research Statement

The goal of the Juvenile Arthritis Pathogenesis Unit is to understand the mechanisms that underlie the development of inflammatory arthritis and cartilage inflammation in children. Advances in genetics have identified many common variants that each contribute a small amount to the overall risk of developing juvenile arthritis. We are studying severe, early-onset arthritis in children to learn more about the role of rare, highly penetrant variants to understand disease mechanisms that will inform individualized treatment approaches. We are currently exploring the role of the toll-like receptor signaling pathway, including MyD88, in the development of childhood arthritis. In addition, we are interested in pathogenic mechanisms underlying the development of relapsing polychondritis (RP), a systemic inflammatory disease of cartilage that can present with joint involvement.

Scientific Publications

Genetics, genomics, and their relevance to pathology and therapy.

Ombrello MJ, Sikora KA, Kastner DL
Best practice & research. Clinical rheumatology.
2014 Apr;
28(2).
doi: 10.1016/j.berh.2014.05.001
PMID: 24974057

The limited role of interferon-γ in systemic juvenile idiopathic arthritis cannot be explained by cellular hyporesponsiveness.

Sikora KA, Fall N, Thornton S, Grom AA
Arthritis and rheumatism.
2012 Nov;
64(11).
doi: 10.1002/art.34604
PMID: 22740319

Update on the pathogenesis and treatment of systemic idiopathic arthritis.

Sikora KA, Grom AA
Current opinion in pediatrics.
2011 Dec;
23(6).
doi: 10.1097/MOP.0b013e32834cba24
PMID: 22045308

Education

SUNY at Buffalo School of Medicine and Biomedical Sciences
M.D.

Cornell University
B.S.

Experience

General Pediatrics
The Johns Hopkins Hospital

Pediatric Rheumatology Fellowship
Cincinnati Children’s Hospital Medical Center

Last Updated: June 2020