Dr. Nagao is a board-certified Dermatologist (Japanese Association of Dermatology) and currently directs a research program that includes basic and pre-translational investigations on skin immunology and immune-mediated diseases. Dr. Nagao is an attending physician on the NIH Clinical Center’s Dermatology Consultation Service.
Dr. Nagao studies the skin-leukocyte-microbiota cross-talks that govern immulogical and structural homeostasis in the skin. Recent studies include the identification of hair follicles as immunological organs that support the homeostasis of dendritic cells and T cells via chemokine and cytokine production, respectively. His laboratory has also generated a mouse model for atopic dermatitis that spontaneously develop eczematous lesions and exhibit naturally occurring dysbiosis. Using this model, Staphylococcus aureus was demonstrated to be a critical element of eczema formation. By utilizing cutting-edge technologies such as single-cell RNA-sequencing, his research currently focuses on macrophages and innate lymphoid cells in the skin to deepen our understanding on the mechanisms that support their residency and functional polarity.