Summary

Dr. Kathleen Baysac obtained her Ph.D. in Molecular Genetics and Genomics at Washington University in Saint Louis. As a postdoctoral research fellow she is working to uncover the molecular mechanisms governing development and maintenance of the skin – the first line of defense protecting the body from pathogenic and mechanical insults.

Research Statement

DLX3 is a critical transcription factor that regulates skin differentiation. Conditional knockout mice, lacking DLX3 in the epidermis, exhibit skin inflammation and barrier dysfunction. Utilizing Bio-ID, ChIP-seq, RNA-seq, and common molecular biology techniques, Dr. Baysac is investigating the interactions between DLX3, its binding partners, and target genes to understand the mechanisms underlying epidermal differentiation and their implications for skin barrier function and various skin pathologies. The overarching goal of this research is to provide novel insights that will be useful for the development of therapeutics to treat skin diseases and conditions.

Scientific Publications

Elevated DDX21 regulates c-Jun activity and rRNA processing in human breast cancers.

Zhang Y, Baysac KC, Yee LF, Saporita AJ, Weber JD
Breast cancer research : BCR.
2014 Sep 28;
16(5).
doi: 10.1186/s13058-014-0449-z
PMID: 25260534

Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations.

Youmans KL, Leung S, Zhang J, Maus E, Baysac K, Bu G, Vassar R, Yu C, LaDu MJ
Journal of neuroscience methods.
2011 Mar 15;
196(1).
doi: 10.1016/j.jneumeth.2010.12.025
PMID: 21219931

A highly toxic cellular prion protein induces a novel, nonapoptotic form of neuronal death.

Christensen HM, Dikranian K, Li A, Baysac KC, Walls KC, Olney JW, Roth KA, Harris DA
The American journal of pathology.
2010 Jun;
176(6).
doi: 10.2353/ajpath.2010.091007
PMID: 20472884

The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populations.

Lipinski MJ, Froenicke L, Baysac KC, Billings NC, Leutenegger CM, Levy AM, Longeri M, Niini T, Ozpinar H, Slater MR, Pedersen NC, Lyons LA
Genomics.
2008 Jan;
91(1).

The Tabby cat locus maps to feline chromosome B1.

Lyons LA, Bailey SJ, Baysac KC, Byrns G, Erdman CA, Fretwell N, Froenicke L, Gazlay KW, Geary LA, Grahn JC, Grahn RA, Karere GM, Lipinski MJ, Rah H, Ruhe MT, Bach LH
Animal genetics.
2006 Aug;
37(4).

Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds.

Parker HG, Kukekova AV, Akey DT, Goldstein O, Kirkness EF, Baysac KC, Mosher DS, Aguirre GD, Acland GM, Ostrander EA
Genome research.
2007 Nov;
17(11).

Education

Washington University
Ph.D., Molecular Genetics and Genomics, 2015

University of California (UC), Davis
B.S., Animal Biology, 2005

Experience

Laboratory Research Technician
National Human Genome Research Institute (NHGRI), 2006 – 2007

Genetics Intern
UC Davis and NHGRI 2004 – 2005

Last Updated: July 2020