Dr. Kathleen Baysac obtained her Ph.D. in Molecular Genetics and Genomics at Washington University in Saint Louis. As a postdoctoral research fellow she is working to uncover the molecular mechanisms governing development and maintenance of the skin – the first line of defense protecting the body from pathogenic and mechanical insults.
DLX3 is a critical transcription factor that regulates skin differentiation. Conditional knockout mice, lacking DLX3 in the epidermis, exhibit skin inflammation and barrier dysfunction. Utilizing Bio-ID, ChIP-seq, RNA-seq, and common molecular biology techniques, Dr. Baysac is investigating the interactions between DLX3, its binding partners, and target genes to understand the mechanisms underlying epidermal differentiation and their implications for skin barrier function and various skin pathologies. The overarching goal of this research is to provide novel insights that will be useful for the development of therapeutics to treat skin diseases and conditions.