Summary

Hanna Kim is a board-certified pediatric rheumatologist who is focused on exploring pathogenesis and novel treatments in juvenile dermatomyositis. During her rheumatology fellowship, Dr. Kim developed a passion for clinical and translational research while studying interferon-mediated autoinflammatory diseases, novel biomarkers, pharmacokinetics, and pharmacodynamics, and safety and efficacy in a compassionate use study with an investigational drug. She went on to become a Lawrence Shulman Scholar and studied the role of interferon and activity-related biomarkers in myositis, particularly juvenile dermatomyositis. She has also been evaluating Janus kinase inhibition in a compassionate use program for refractory juvenile dermatomyositis.

Dr. Kim was appointed as an Assistant Clinical Investigator in 2020 and is also an attending physician on the NIH Pediatric Rheumatology Consultation Service. She is actively involved in a range of organizations including the American College of Rheumatology (ACR), the Childhood Arthritis Rheumatology Research Alliance, and the International Myositis Assessment and Clinical Studies Group.

She has received numerous local, national, and international awards and honors, including NIAMS Group Merit Award, ACR Distinguished Fellow Award, Rheumatology Research Foundation Pediatric Research Award, Pediatric Rheumatology European Society Young Investigator Travel Award, selection for the ACR-European League Against Rheumatism Early Investigator Exchange Program, and best abstract at the Global Conference on Myositis. She has also given national and international presentations.

Research Statement

The Juvenile Myositis Therapeutic and Translational Studies Unit is a research group focused on better understanding the pathogenesis of juvenile myositis, particularly inflammatory and immune mechanisms, and improved therapy. This is approached by discovery biomarker analysis utilizing broad expression such as transcriptomic and proteomic analysis in juvenile dermatomyositis, a rare autoimmune system vasculopathy with notable involvement of skin with characteristic rashes and muscle inflammation.  Another approach is looking at how biomarkers in juvenile myositis compare to Mendelian autoinflammatory disease and further analysis of juvenile myositis separated by myositis autoantibody subgroups which have some distinct patterns of features.

Regarding treatment, we investigate novel treatments in small clinical trials in juvenile myositis with the goal of establishing more targeted therapy ideally with fewer side-effects and greater efficacy.  We hope that through better understanding pathogenesis can be paired with the investigation of novel therapies that can lead to better management and improved quality of life for people with juvenile myositis.

Scientific Publications

Janus kinase (JAK) inhibition with baricitinib in refractory juvenile dermatomyositis.

Kim H, Dill S, O'Brien M, Vian L, Li X, Manukyan M, Jain M, Adeojo LW, George J, Perez M, Grom AA, Sutter M, Feldman BM, Yao L, Millwood M, Brundidge A, Pichard DC, Cowen EW, Shi Y, Lu S, Tsai WL, Gadina M, Rider LG, Colbert RA
Annals of the rheumatic diseases.
2020 Aug 25;
pii: annrheumdis-2020-218690. doi: 10.1136/annrheumdis-2020-218690
PMID: 32843325

Expression of interferon-regulated genes in juvenile dermatomyositis versus Mendelian autoinflammatory interferonopathies.

Kim H, Gunter-Rahman F, McGrath JA, Lee E, de Jesus AA, Targoff IN, Huang Y, O'Hanlon TP, Tsai WL, Gadina M, Miller FW, Goldbach-Mansky R, Rider LG
Arthritis research & therapy.
2020 Apr 6;
22(1).
doi: 10.1186/s13075-020-02160-9
PMID: 32252809

Development of a Validated Interferon Score Using NanoString Technology.

Kim H, de Jesus AA, Brooks SR, Liu Y, Huang Y, VanTries R, Montealegre Sanchez GA, Rotman Y, Gadina M, Goldbach-Mansky R
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
2018 Apr;
38(4).
doi: 10.1089/jir.2017.0127
PMID: 29638206

Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients.

Kim H, Brooks KM, Tang CC, Wakim P, Blake M, Brooks SR, Montealegre Sanchez GA, de Jesus AA, Huang Y, Tsai WL, Gadina M, Prakash A, Janes JM, Zhang X, Macias WL, Kumar P, Goldbach-Mansky R
Clinical pharmacology and therapeutics.
2018 Aug;
104(2).
doi: 10.1002/cpt.936
PMID: 29134648

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies.

Sanchez GAM, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, de Jesus AA, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JJ, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R
The Journal of clinical investigation.
2018 Jul 2;
128(7).
doi: 10.1172/JCI98814
PMID: 29649002

Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America.

Spencer CH, Rouster-Stevens K, Gewanter H, Syverson G, Modica R, Schmidt K, Emery H, Wallace C, Grevich S, Nanda K, Zhao YD, Shenoi S, Tarvin S, Hong S, Lindsley C, Weiss JE, Passo M, Ede K, Brown A, Ardalan K, Bernal W, Stoll ML, Lang B, Carrasco R, Agaiar C, Feller L, Bukulmez H, Vehe R, Kim H, Schmeling H, Gerstbacher D, Hoeltzel M, Eberhard B, Sundel R, Kim S, Huber AM, Patwardhan A, Pediatric Rheumatologist Collaborators.
Pediatric rheumatology online journal.
2017 Jun 13;
15(1).
doi: 10.1186/s12969-017-0174-0
PMID: 28610606

Insights from Mendelian Interferonopathies: Comparison of CANDLE, SAVI with AGS, Monogenic Lupus.

Kim H, Sanchez GA, Goldbach-Mansky R
Journal of molecular medicine (Berlin, Germany).
2016 Oct;
94(10).

Education

University of California at Irvine (UCI)
M.D.

Virginia Commonwealth University (VCU)
M.S.

California Institute of Technology (Caltech)
B.S.

Experience

Residency in Pediatrics
George Washington University / Children’s National Medical Center

Pediatric Rheumatology Fellowship
Nemours/Alfred I. DuPont Hospital for Children (Wilmington, DE), Children’s National Health System (DC), and NIH-NIAMS.

Last Updated: September 2020