Danielle Chisolm, Ph.D., graduated with a degree in biology from Bethune-Cookman University in 2012. After graduating, she participated in a Post-Baccalaureate program at the University of North Carolina at Chapel Hill, working under the direction of Dr. Nathaniel Moorman to study the molecular pathogenesis of human cytomegalovirus. Dr. Chisolm performed her graduate training at the University of Alabama at Birmingham under the leadership of Dr. Amy Weinmann. Her doctoral research defined a novel role for the metabolite alpha-ketoglutarate in promoting the IL-2-sensitive program in T cells. This was done in part through influencing changes in genome organization.

In 2018, Dr. Chisolm began her postdoctoral research with Dr. John O’Shea to expand her knowledge of the interconnections between transcription and metabolism and how this translates at the epigenetic level. Her current work aims to define the role a novel transcription factor plays in regulating T cell differentiation. In 2020, she was awarded a Postdoctoral Research Associate Training grant from the National Institute of General Medical Sciences. In 2021, Dr. Chisolm was named an Independent Research Scholar. Through this appointment, she will serve as a junior faculty member in the NIAMS, leading an independent team of researchers. 

Research Statement

Dr. Chisolm’s main research goal is to study the molecular mechanisms by which external cues regulate T cell differentiation. Many external cues are important in regulating T cell differentiation gene programs, including but not limited to cytokines, TCR-signaling, and metabolism. She is interested in understanding how these different cues are responsible for promoting cellular programming decisions at the epigenetic level to fine-tune an appropriate immune response. 

Scientific Publications

Translating JAKs to Jakinibs.

Gadina M, Chisolm DA, Philips RL, McInness IB, Changelian PS, O'Shea JJ
J Immunol.
2020 Apr 15;
doi: 10.4049/jimmunol.1901477
PMID: 32253269

Defining Genetic Variation in Widely Used Congenic and Backcrossed Mouse Models Reveals Varied Regulation of Genes Important for Immune Responses.

Chisolm DA, Cheng W, Colburn SA, Silva-Sanchez A, Meza-Perez S, Randall TD, Weinmann AS
2019 Jul 16;
doi: 10.1016/j.immuni.2019.05.006
PMID: 31248780

Metabolites, genome organization, and cellular differentiation gene programs.

Chisolm DA, Weinmann AS
Curr Opin Immunol.
2018 Apr;
doi: 10.1016/j.coi.2018.01.005
PMID: 29525347

Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation.

Chisolm DA, Weinmann AS
Annu Rev Immunol.
2018 Apr 26;
doi: 10.1146/annurev-immunol-042617-053127
PMID: 29328786

CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs.

Chisolm DA, Savic D, Moore AJ, Ballesteros-Tato A, León B, Crossman DK, Murre C, Myers RM, Weinmann AS
2017 Aug 15;
doi: 10.1016/j.immuni.2017.07.015
PMID: 28813658


University of Alabama at Birmingham, Birmingham, AL
Ph.D., Microbiology (2018)

Bethune-Cookman University, Daytona Beach, FL
B.S., Biology (2012)


Independent Research Scholar
NIAMS, NIH, Bethesda MD (2021-present)

Postdoctoral Fellowship
NIAMS, NIH, Bethesda MD (2018-2021)

Doctoral Research
University of Alabama at Birmingham, AL (2013-2018)

Postbaccalaureate Research
University of North Carolina at Chapel Hill, NC (2012-2013)

Last Updated: