Summary

Dr. Benhalevy’s interests lie in how cellular pathways are affected by the spatial organization of organelles and molecules. He is studying the mechanisms that rely on RNA localization and RNA-protein interactions.

Research Statement

Intracellular compartmentalization is highly regulated and conserved. I am interested in how cellular pathways are affected by the spatial organization of organelles and molecules. Specifically, I study mechanisms that rely on RNA localization and RNA-protein interactions.

Scientific Publications

Proximity-CLIP provides a snapshot of protein-occupied RNA elements in subcellular compartments.

Benhalevy D, Anastasakis DG, Hafner M
Nature methods.
2018 Dec;
15(12).
doi: 10.1038/s41592-018-0220-y
PMID: 30478324

The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation.

Benhalevy D, Gupta SK, Danan CH, Ghosal S, Sun HW, Kazemier HG, Paeschke K, Hafner M, Juranek SA
Cell reports.
2017 Mar 21;
18(12).
doi: 10.1016/j.celrep.2017.02.080
PMID: 28329689

PAR-CLIP and streamlined small RNA cDNA library preparation protocol for the identification of RNA binding protein target sites.

Benhalevy D, McFarland HL, Sarshad AA, Hafner M
Methods (San Diego, Calif.).
2017 Apr 15;
118-119().
doi: 10.1016/j.ymeth.2016.11.009
PMID: 27871973

Evidence for a cytoplasmic pool of ribosome-free mRNAs encoding inner membrane proteins in Escherichia coli.

Benhalevy D, Biran I, Bochkareva ES, Sorek R, Bibi E
PloS one.
2017;
12(8).
doi: 10.1371/journal.pone.0183862
PMID: 28841711

Model Uracil-Rich RNAs and Membrane Protein mRNAs Interact Specifically with Cold Shock Proteins in Escherichia coli.

Benhalevy D, Bochkareva ES, Biran I, Bibi E
PloS one.
2015;
10(7).
doi: 10.1371/journal.pone.0134413
PMID: 26225847

The VAP protein family: from cellular functions to motor neuron disease.

Lev S, Ben Halevy D, Peretti D, Dahan N
Trends in cell biology.
2008 Jun;
18(6).
doi: 10.1016/j.tcb.2008.03.006
PMID: 18468439

Education

Tracking mRNAs during the biogenesis of integral membrane proteins in Escherichia coli, Feinberg Graduate School, Weizmann Institute of Science, Laboratory of Prof. Eitan Bibi
Ph.D.

Nir2 and VAP-B proteins function in ER-Golgi membrane contact sites and lipid homeostasis, Feinberg Graduate School, Weizmann Institute of Science, Laboratory of Prof. Sima Lev
M.Sc.

The George S. Wise Faculty Program for Outstanding Students, Tel-Aviv University
B.Sc., Life Sciences

Last Updated: August 2020