I study the molecular biology of tooth root development and mineralization, with interests including genes, mechanisms, diseases, and novel regeneration strategies. My overarching objective as a researcher in the dental-oral-craniofacial field is to understand the molecular mechanisms driving tooth root formation and bring new insights to novel approaches for regenerating tissues and restoring function. Specific areas of inquiry have included: phosphate/pyrophosphate metabolism, developmental regulators of cementum, cementoblast and cementocyte functions, roles of extracellular matrix (ECM) proteins in dental mineralization, and manifestations of skeletal/endocrine diseases in dental tissues. Studies have focused on several aspects of development and pathology in the dentoalveolar mineralized tissues, including enamel, dentin, cementum, and bone, and have encompassed several mouse models where mineralization status was affected, including models of hypophosphatasia, hypermineralization, X-linked hypophosphatemic rickets (XLH), hyperphosphatemia, and altered extracellular matrix. Techniques routine to this work include histology, histomorphometry, craniofacial measurements, immunohistochemistry, in situ hybridization, non-decalcified histology and differential staining, radiography, micro-computed tomography, and scanning and transmission electron microscopy. More broadly, I am also interested in how knowledge gained from the study of dental-oral-craniofacial connective tissues may be applied more widely to skeletal development, disease, wound healing, and regeneration.