The aim of my research is to gain insight into how a cytoskeleton protein and an RNA-binding protein coordinate gene expression in breast cancer cells.
My current focus is understanding the interplay between K19 and hnRNP K in regulating gene expression. The first goal is to identify hnRNP K targets in cytoplasmic and nuclear compartments. I am investigating the possibility that K19 localizes hnRNP K at the cytoplasm and stabilizes hnRNP K mRNA targets at 3’ UTR, thereby increasing the translation of hnRNP K targets. The stability of hnRNP K mRNA targets promotes many cellular processes that have been known to implicate tumorigenesis. One such process may be dysregulation in the p53 pathway, which ultimately leads to proliferation in cells. Therefore, identifying hnRNP K targets will allow for further exploration of this theory.