Andrew received his B.S. in Biochemistry from Temple University (Philadelphia, PA) in 2012 and his Ph.D. in Genetics, Genomics, and Cancer Biology from Thomas Jefferson University (Philadelphia, PA) in 2018. During his graduate training in the lab of Dr. Mỹ Mahoney, he studied how cell-cell adhesion complex components interfaced with deregulated cellular signaling cascades to alter malignant progression in the skin. Additionally, Andrew investigated how these same interwoven adhesion components and signaling cascades contributed to wound healing in the healthy, non-malignant skin. Pursuing his interest in cutaneous wound healing, he joined the lab of Dr. Maria Morasso in the Fall of 2018. Using molecular biological techniques, murine studies, and various NGS techniques from in vivo and in vitro sources, he will attempt to elucidate how the oral epithelium rapidly employs a regeneration program in response to tissue damage versus the slower repair program employed by the skin.

Scientific Publications

Overexpression of Desmoglein 2 in a Mouse Model of Gorlin Syndrome Enhances Spontaneous Basal Cell Carcinoma Formation through STAT3-Mediated Gli1 Expression.

Brennan-Crispi DM, Overmiller AM, Tamayo-Orrego L, Marous MR, Sahu J, McGuinn KP, Cooper F, Georgiou IC, Frankfurter M, Salas-Alanis JC, Charron F, Millar SE, Mahoney MG, Riobo-Del Galdo NA
J Invest Dermatol.
2019 Feb;
doi: 10.1016/j.jid.2018.09.009
PMID: 30291846

Enhancement of Cutaneous Wound Healing by Dsg2 Augmentation of uPAR Secretion.

Cooper F, Overmiller AM, Loder A, Brennan-Crispi DM, McGuinn KP, Marous MR, Freeman TA, Riobo-Del Galdo NA, Siracusa LD, Wahl JK 3rd, Mahoney MG
J Invest Dermatol.
2018 Nov;
doi: 10.1016/j.jid.2018.04.024
PMID: 29753032

Feasibility study for clinical application of caspase-3 inhibitors in Pemphigus vulgaris.

Hariton WVJ, Galichet A, Vanden Berghe T, Overmiller AM, Mahoney MG, Declercq W, Müller EJ
Exp Dermatol.
2017 Dec;
doi: 10.1111/exd.13458
PMID: 29105150

Desmoglein 2 modulates extracellular vesicle release from squamous cell carcinoma keratinocytes.

Overmiller AM, Pierluissi JA, Wermuth PJ, Sauma S, Martinez-Outschoorn U, Tuluc M, Luginbuhl A, Curry J, Harshyne LA, Wahl JK 3rd, South AP, Mahoney MG
2017 Aug;
doi: 10.1096/fj.201601138RR
PMID: 28438789

c-Src/Cav1-dependent activation of the EGFR by Dsg2.

Overmiller AM, McGuinn KP, Roberts BJ, Cooper F, Brennan-Crispi DM, Deguchi T, Peltonen S, Wahl JK 3rd, Mahoney MG
2016 Jun 21;
doi: 10.18632/oncotarget.7675
PMID: 26918609

Palmitoylation of Desmoglein 2 Is a Regulator of Assembly Dynamics and Protein Turnover.

Roberts BJ, Svoboda RA, Overmiller AM, Lewis JD, Kowalczyk AP, Mahoney MG, Johnson KR, Wahl JK 3rd
J Biol Chem.
2016 Nov 25;
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