My major research interest is represented by the study of the regulation of gene expression. During my PhD I have focused my attention on the mechanisms by which oncogenic transcription factors may promote cancer development by de-regulating transcription. Currently, I am focused on the study of the relationship between chromatin architecture and gene regulation on genomic scale in immune cells. Our main goal is to elucidate general mechanisms of transcription factors usage, to start to shed light onto the “grammar” which regulates the binding to DNA and the activity of these molecules in different cell types.
Besides this, we are trying to use different genetic engineering techniques to generate transgenic mouse models to produce antibodies of potential clinical and investigative interest.