NIAMS IRP Retreat 2014


Lister Hill Auditorium
NIH campus, Bethesda
May 29-30, 2014

Day 1: Thursday, May 29
Day 2: Friday, May 30

Day 1:       Thursday, May 29

8:00 a.m. - 8:30 a.m. Registration
8:30 a.m. – 8:45 a.m.

Chair, Bob Colbert, M.D., Ph.D., Deputy Clinical Director, NIAMS
Co-Chair, Massimo Gadina, Ph.D., Director, Office of Science and Technology, NIAMS
Steve Katz, M.D., Ph.D., Director, NIAMS
John O’Shea, M.D., NIAMS Scientific Director

8:45 a.m. – 9:45 a.m. Keynote speaker: Yasmine Belkaid, Ph.D.
“Immune System-Microbiota: Alliances and Mésalliance”
Senior Investigator & Chief, Mucosal Immunology Section NIAID
9:45 a.m. – 10:45 a.m. Keynote speaker: Glen N. Barber, Ph.D.
“STING, Cytosolic DNA Signaling and Inflammation”
Professor and Chair, Department of Cell Biology, University of Miami Miller School of Medicine
10:45 a.m. - 12:00 p.m. Poster Session I
12:00 p.m. – 1:15 p.m. Lunch Break
1:15 p.m. – 2:15 p.m.

General Session I
Moderator: Raphaela Goldbach-Mansky, M.D.

Yin Liu, Ph.D.
“De Novo Gain of Function Mutations in TMEM173 (STING) Cause a Vasculitis and Pulmonary Syndrome”
Translational Autoinflammatory Disease Section

Julie Erthal, M.A.
“DLX3 Regulates Bone Mass by Targeting Genes Supporting Osteoblast Differentiation and Mineral Homeostasis”
Laboratory of Skin Biology

Jehad Edwan, Ph.D.
“Regulation of Mitochondrial STAT3 Activity Controls NLRP3 Inflammasome-Dependent Release of IL-1β and Pyronecrosis”
Pediatric Translational Research Branch

2:15 p.m. – 3:15 p.m. Keynote speaker: Meredith Wadman, B.M., B.Ch.
“Why You Should (or Shouldn’t) Talk to Journalists, and Rules of the Road for Doing So”
Future Tense Fellow
The New America Foundation, Washington, DC
3:15 p.m. – 4:15 p.m. Poster Session I (continued)
4:15 p.m. – 4:55 p.m.

General Session II
Moderator: Vittorio Sartorelli, M.D.

Michael Ombrello, M.D.
“Mapping of Behcet’s Disease Risk Within MHC Class I Molecules Implicates Peptide Binding and the Regulation of Cytotoxic Cells in Behcet’s Disease Pathogenesis”
Office of Clinical Director

Carolyne Smith, B.S.
“Neutrophil Extracellular Traps as a Source of High Density Lipoprotein Oxidation in Lupus-Related Cardiovascular Disease”
Systemic Autoimmunity Branch

Day 2:       Friday, May 30

8:30 a.m. – 9:30 a.m. Welcome
Co-Chair, Massimo Gadina, Ph.D.

Keynote speaker: Lionel Ivashkiv, M.D.
“Epigenetic Regulation of Cytokine Responses in Health and Disease (tent title)”
Professor, Medicine and Immunology
David H. Koch Chair in Arthritis and Tissue Degeneration
Hospital for Special Surgery Genomics Center, New York, New York
9:30 a.m. – 10:30 a.m. Keynote speaker: Hao Wu, Ph.D.
“Imaging is Everything: Immune Signaling Pathways (tent title)”
Asa and Patricia Springer Professor, Department of Biological Chemistry and Molecular Pharmacology
Senior Investigator, Program in Cellular and Molecular Medicine
Boston Children’s Hospital and Harvard Medical School
10:30 a.m. – 11:10 a.m.

General Session III
Moderator: Maria Morasso, Ph.D.

Michael Bonelli, Ph.D.
“Epigenetic Memory Imprints Regulatory T Cell Fate”
Molecular Inflammation and Immunology Branch

Hong Jun Wang, Ph.D.
“The Histone Chaperone Spt6 Counteracts Polycomb Repressive Complex 2”
Laboratory of Muscle Stem Cells and Gene Regulation

11:10 a.m. – 1:30 p.m. Poster Session II and Lunch
1:30 p.m. – 2:30 p.m.

NIAMS IRP Investigators Session

Mariana Kaplan, M.D.
”NETworks in Systemic Autoimmunity: From Loss of Tolerance to End Organ Damage”
Senior Investigator and Chief, Systemic Autoimmunity Branch, NIAMS

Markus Hafner, Ph.D.
“Dissection of Targets and Function of the Germline-Restricted RNA Binding Protein Dead End 1 (DND1)”
Earl Stadtman Investigator, NIAMS

2:30 p.m. – 3:10 p.m.

General Session IV - Abstract Presentations
Moderator: Richard Siegel, M.D., Ph.D.

Yasuko Furumoto, Ph.D.
“JAK Inhibitors for Lupus:? Preclinical Assessment of Tofacitinib in an SLE Model”
Office of Science and Technology

Laura Vian, Ph.D.
“Defining CTCF Physiological Roles: Rules of the ‘CTCF Code’”
Laboratory of Molecular Immunogenetics

3:10 p.m. – 3:25 p.m. Break
3:25 p.m. – 4:10 p.m.

General Session V -Research Proposals by Second Year Clinical Fellows
Moderator: James Katz, M.D.

Daniella Schwartz, M.D.
“Retinoic Acid and T Cells: Transcriptomic Analyses Reveals Foxp3-Dependent and Independent Effects”
Rheumatology Fellowship and Training Branch

Pravitt Gourh, M.D.
“GRASP: Genomic Research in African-American Scleroderma Patients”
Rheumatology Fellowship and Training Branch

Angeliki Giannelou, M.D.
TRNT1 Missense Mutations Define a New Periodic Fever Syndrome”
Rheumatology Fellowship and Training Branch

4:10 p.m. – 4:30 p.m.

Concluding remarks
John O’Shea, M.D., NIAMS Scientific Director