NIAMS Update August 2010

NIAMS - National Institute of Arthritis and Musculoskeletal and Skin Diseases
Update - An online resource for the NIAMS Coalition, Council, and Colleague
August 19, 2010
The NIAMS Update is a monthly digest published for those interested in the latest scientific news and resources on diseases of the bones, joints, muscles, and skin. We encourage further dissemination of this resource.
Contact Information

Office of Communications and Public Liaison

Janet S. Austin, Ph.D.

Melanie M. Martinez, M.P.A.
Public Liaison Officer

Trish Reynolds, R.N., M.S.
Media Liaison

NIH Osteoporosis and Related Bone Diseases National Resource Center Web site
NIH Osteoporosis and Related Bone Diseases ~ National Resource Center Web site.

New NIH Web Site Offers Easy Access to Information on Bone Health
A new Web resource providing the general public with the latest science-based information on bone health and bone disease is now available through the NIAMS-operated National Institutes of Health (NIH) Osteoporosis and Related Bone Diseases ~ National Resource Center (NRC). In addition to a fresh new look, the site offers more ways to search for scientifically accurate bone health information, including by audience type, language, reading level and disease. Explore the new site at


Rare Gene Variants Associated With Rheumatoid Arthritis, Type 1 Diabetes
Scientists funded by NIH, the Alliance for Lupus Research and Massachusetts General Hospital have discovered that rare variants of a gene that encodes the enzyme sialic acid acetylesterase (SIAE) are associated with several autoimmune diseases, especially rheumatoid arthritis and type 1 diabetes. Their findings, published online in Nature, suggest that SIAE plays an important role in autoimmunity. They also highlight the promise that rare variant analysis holds for unraveling complex, multigene diseases.

NIH Genetic Collaboration Brings New Meaning to the Silk Road
NIAMS researchers have found susceptibility to Behcet’s disease, a painful, inflammatory condition, to be associated with genes involved in the body’s immune response.

NIH-Funded Researchers Make Progress Toward Regenerating Tissue to Replace Joints
A team of NIH-funded researchers has successfully regenerated rabbit joints using a cutting-edge process to form the joint inside the body, or in vivo. Regenerative in vivo procedures are performed by stimulating previously irreparable organs or tissues to heal themselves. In this study, bioscaffolds, or three-dimensional structures made of biocompatible and biodegradable materials in the shape of the tissue, were infused with a protein to promote growth of the rabbit joint.

NIH Announces New Awards in Program to Expand Interdisciplinary Research Careers in Women’s Health
Almost $6 million has been awarded to investigators and programs to help researchers in the early stages of careers in women’s health research. The funding is from NIH’s Office of Research on Women’s Health and other co-sponsors. The money will go to 12 new and continuing Building Interdisciplinary Research Careers in Women’s Health programs nationwide. This is the fifth funding round of an innovative, interdisciplinary career development program for men and women junior faculty in women’s health research.

After 40 Years, NIH-Supported Researchers Identify Possible New Treatment for Severe Vasculitis
Investigators have made a major advance in treating people with a severe form of vasculitis, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, a rare but devastating disease of blood vessels. In a six-month study, a new treatment strategy provided the same benefits as the current standard of care used for more than 40 years, but required less frequent treatments. Early results also suggest that patients with disease relapses—typically recurrences of fever, fatigue, kidney damage or bleeding in the lungs—respond better to the new regimen.

NIH Expands National Network for Transforming Clinical and Translational Research: Nine Institutions to Receive $255 Million Over Five Years to Help Scientists Bridge Laboratory Discoveries to Patient Treatments
Nine health research centers have received funds to develop ways to reduce the time it takes for clinical research to become treatments for patients. The funds were awarded as part of the Clinical and Translational Science Awards program, which is led by NIH’s National Center for Research Resources.


Save the Date: NIAMS Advisory Council Meeting
The next NIAMS Advisory Council Meeting will be held September 28, 2010, in Building 31, 6th floor, C Wing, Conference Room 6, NIH Campus.


NIH Research Matters
NIH Research Matters is a review of NIH research from the Office of Communications and Public Liaison, Office of the Director, NIH.

Some Stem Cells Find it Hard to Forget
Scientists have discovered why induced pluripotent stem cells—which many hope will replace the need for embryonic stem cells one day—don’t always function as well as the embryonic variety. The researchers also developed ways to get around the problem.

NIH Public Bulletin
Read about the latest public events, activities and health information resources from NIH in the latest issue of the NIH Public Bulletin.

NIH News in Health
Read practical health information in NIH News in Health, which is reviewed by NIH’s medical experts and is based on research conducted either by NIH’s own scientists or by our grantees at universities and medical schools around the country.

A man scratchingItchy, Scaly Skin? Living With Psoriasis
The thick, red, scaly skin of psoriasis can be not only painful but also embarrassing. You may have it or know someone who does. Psoriasis affects more than 3 percent of the U.S. population. August is Psoriasis Awareness Month. It’s a good time to learn about this uncomfortable illness.

Revised Publication

Questions and Answers about Hip Replacement
This booklet contains information about hip replacement surgery. It discusses the surgical procedure and the types of prostheses that are used. It provides information on postoperative recovery, rehabilitation and possible complications. Information is also provided on current research.

Funding Announcements
NIH Roadmap Initiative Announcements

2011 NIH Director’s Pioneer Award Program (DP1)
Letters of Intent Receipt Date: Not applicable
Application Receipt Date: September 13, 2010

2011 NIH Director’s New Innovator Award Program (DP2)
Letters of Intent Receipt Date: Not applicable
Application Receipt Date: September 20, 2010

NIAMS Research Announcement

2010 BioMed-ISS Pre-Application Meeting Information—Biomedical Research on the International Space Station (ISS) (PAR-09-120)

Other Research Announcements

Epigenomics of Human Health and Disease (R01)
Letters of Intent Receipt Date: August 29, 2010
Application Receipt Date: September 29, 2010

Informatics, Coordination and Service Center for the Mutant Mouse Regional Resource Centers (U42)
Letters of Intent Receipt Date: Not applicable
Application Receipt Date: October 7, 2010

Clinical and Translational Science Coordinating Center (U54)
Letters of Intent Receipt Date: December 15, 2010
Application Receipt Date: January 12, 2011

Effects of the Social Environment on Health: Measurement, Methods and Mechanisms (R01)
Letters of Intent Receipt Date: December 6, 2010
Application Receipt Date: January 6, 2011

Advancing Novel Science in Women’s Health Research (ANSWHR) (R21)
Letters of Intent Receipt Date: Not applicable
Application Receipt Dates: October 16, 2010; October 16, 2011; and October 16, 2012, for new applications; November 16, 2010; November 16, 2011; and November 16, 2012, for resubmission applications

Neurological Sciences Academic Development Award (K12)
Letters of Intent Receipt Date: Not applicable
Application Receipt Dates: October 12, 2010, and October 12, 2011, for new applications; November 12, 2010, and November 12, 2011, for resubmission and renewal applications
AIDS Application Receipt Dates: January 7, 2011, and January 7, 2012

NIH Extramural Loan Repayment Programs (LRP)

Extramural Loan Repayment Program for Clinical Researchers (LRP-CR): Program-Specific Information

Extramural Pediatric Research Loan Repayment Program (LRP-PR): Program-Specific Information

Extramural Loan Repayment Program for Health Disparities Research (LRP-HDR): Program-Specific Information

Extramural Clinical Research Loan Repayment Program for Individuals from Disadvantaged Backgrounds (LRP-IDB): Program-Specific Information

NIH Offers SBIR Niche Assessment Program to Phase I Awardees

Update on Applicability of the Shelf Life Extension Program (SLEP)

Enhancing Peer Review: New NIH Policy on Post-Submission Application Materials

IACUC 101 and 201 PLUS Workshops: August 18–19, 2010, in San Francisco, CA

Biosafety in Microbiological and Biomedical Laboratories (BMBL): 5th Edition

Animal Welfare and Scientific Research: 1985 to 2010 Symposium plus IACUC 101 and AWIC Workshops

If you would like to review information about funding opportunities more frequently than our monthly updates allow, see the NIH Guide for Grants and Contracts, the primary source for information about NIH funding opportunities. You can also request a weekly Table of Contents from the NIH Guide.